148927-35-9

Upstream product

• 19861-62-2 2,4-dichloro-5-nitrobenzoic acid 
• 713-28-0 2,4-dichloro-5-nitro benzoyl chloride 
• 109308-73-8 ethyl ester of 2-(5-nitro-2,4-dichlorobenzoyl)-3-ethoxyacrylic acid 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 
• 371-40-4 4-fluoroaniline 
• 148926-94-7 ethyl ester of 3-dimethylamino-2-(5-nitro-2,4-dichlorobenzoyl)acrylic acid 
• 161040-32-0 (Z)-2-(2,4-Dichloro-5-nitro-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid ethyl ester 

Downstream Products

• 161040-82-0 6-Amino-1-(4-fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 162558-46-5 6-Amino-1-(4-fluoro-phenyl)-4-oxo-7-thiomorpholin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 1026854-88-5 6-amino-1-(4-fluoro-phenyl)-4-oxo-7-(4-pyridin-2-yl-piperazin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 368839-20-7 7-chloro-1-(4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxoquinoline-3-carboxylic acid 
• 161040-64-8 1-(4-Fluoro-phenyl)-7-(4-methyl-piperazin-1-yl)-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-65-9 1-(4-Fluoro-phenyl)-6-nitro-4-oxo-7-thiomorpholin-4-yl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 1027309-89-2 1-(4-fluoro-phenyl)-6-nitro-4-oxo-7-(4-pyridin-2-yl-piperazin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids

Various 1-(substituted)-1,4-dihydro-6-nitro-4-oxo-7-(sub-secondary amino)-quinoline-3-carboxylic acids were synthesized from 2,4-dichlorobenzoic acid by six step synthesis. The compounds were evaluated for antimycobacterial in vitro and in vivo against My

6-Aminoquinolones: A new class of quinolone antibacterials?

A series of quinolone- and 1,8-naphthyridone-3-carboxylic acids, designed by previous QSAR studies and characterized by an amino group at the C-6 position instead of the usual fluorine atom, were synthesized for the first time and evaluated for in vitro antibacterial activity. All of the synthesized compounds maintain good activity against Gram-negative bacteria (Pseudomonas aeruginosa excluded), and those compounds having a thiomorpholine group as the C-7 substituent also have good activity against Gram-positive bacteria. Some aspects of structure activity relationships associated with the C-1, C-5, C-7, and C-8 substituents are also discussed. Derivatives 18g and 38g displayed the best activity with geometric mean MICs of 0.45 and 0.66-0.76 μg/mL against Gram-negative and Gram-positive bacteria, respectively. This antimicrobial activity reflects their ability to inhibit bacterial DNA-gyrase. The results of this study show that, while the C-6 fluorine is still the preferred substituent, good activity can still be obtained by replacing it with an amino group.