713-93-9Relevant articles and documents
Direct Synthesis of N,N-Dimethylated and β-Methyl N,N-Dimethylated amines from nitriles using methanol: Experimental and computational studies
Paul, Bhaskar,Shee, Sujan,Panja, Dibyajyoti,Chakrabarti, Kaushik,Kundu, Sabuj
, p. 2890 - 2896 (2018/04/14)
Direct and selective synthesis of N,N-dimethylated amines from nitriles using methanol as C1 building blocks is reported using an air- and moisture-stable ruthenium complex. Following this process, various aromatic as well as aliphatic nitriles were converted to the corresponding N-methylated amines. Interestingly, tandem C-methylation as well as N-methylation was achieved by introducing multiple methyl groups. The practical aspect of this process was revealed by preparative-scale reactions with different nitriles and the synthesis of anti-allergic drug "avil". Several kinetic experiments and detailed DFT calculations were carried out to understand the mechanism of this process.
Simple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis
Dong, Zhe,Wang, Jianchun,Dong, Guangbin
supporting information, p. 5887 - 5890 (2015/05/27)
Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by commercially available AsPh3 as the ligand and a unique "acetate cocktail". Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work.
N-2-hydroxyethyl N'-alkylpiperazines and benzylamines: Chemistry and pharmacology
Scotto di Tella,Dessaigne,Boyer,et al.
, p. 131 - 135 (2007/10/02)
The authors have prepared some benzylamine derivatives and established a structure-antidysrhythmic activity relationship. Most of the compounds exhibited significant activity. One also showed interesting anticalcium activity.
