71424-95-8

Usage

Biological Activity

Activator of GABA aminotransferase. Anticonvulsant.

Upstream product

• 336191-10-7 ethyl 4-amino-3-methyl butanoate 
• 128062-16-8 methyl (S)-3-methyl-N-(4-methoxycarbonyl)-butanoate 
• 31551-66-3 (S)-(-)-4-methylpyrrolidin-2-one 
• 19013-37-7 dimethyl 3-methylglutarate 
• 128062-15-7 (R)-3-methylglutaramide 
• 1443453-34-6 diethyl 2-[(2R)-1-nitropropan-2-yl]propanedioate 
• 1443453-35-7 ethyl (4R)-4-methyl-2-oxopyrrolidine-3-carboxylate 
• 162103-41-5 (1'S,4R)-4-methyl-1-(1-phenyleth-1'-yl)pyrrolidin-2-one 
• 162103-38-0 (1'S,4S)-4-methyl-1-(1-phenyleth-1'-yl)pyrrolidin-2-one 
• 811449-06-6 dithiocarbonic acid O-ethyl ester S-[5-oxo-1-(1-phenyl-ethyl)-pyrrolidin-3-ylmethyl] ester 
• 811449-04-4 (S)-N-allyl-2-bromo-N-(1-phenyl-ethyl)acetamide 
• 2985-50-4 3-methyl-4-nitrobutyric acid ethyl ester 
• 4166-53-4 3-methylglutaric anhydride 
• 2996-58-9 4-methyl-2-pyrrolidinone 

Relevant academic research and scientific papers

Enantioselective synthesis of γ-aminobutyric acid derivatives by Ni(II)-catalyzed reaction of diethyl malonate with nitroalkenes

A new synthetic approach to (3R)-4-amino-3-methylbutyric acid and [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide [(R)-phenotropil] has been developed. Asymmetric center with a required configuration has been generated via enantioselective addition of dieth

The 5-exo-trig radical cyclization reaction under reductive and oxidative conditions in the synthesis of optically pure GABA derivatives

Free radical precursors 4a and 4b were synthesized and treated under reductive or oxidative conditions to obtain the corresponding optically pure pyrrolidinones 5-8, which were subsequently transformed into corresponding optically pure GABA derivatives 9-11. When reductive radical conditions (4a→7 and 8) were used, a Ph1-5 migration product 14 was obtained; presumably depending upon the specific conformation of the rotamer precursor and also 14 was found to be a kinetic product.

CHEMOENZYMATIC SYNTHESIS OF (R)- AND (S)-4-AMINO-3-METHYLBUTANOIC ACIDS

(R)- and (S)-4-Amino-3-methylbutanoic acids were synthesized in high yields via initial enantioselective hydrolysis of dimethyl 3-methylglutarate to methyl (R)-3-methylglutarate with pig liver esterase.The ester group was converted to an amine to give (R)-4-amino-3-methylbutanoic acid; the carboxylic acid was converted to an amine to give (S)-4-amino-3-methylbutanoic acid.