71441-07-1

Upstream product

• 17610-14-9 1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethan-1-one 
• 71441-08-2 ethyl 4-(diethoxyphosphorylmethyl)benzoate 
• 4834-33-7 1,1,3,3-tetramethylindan 
• 69251-15-6 α-methyl-(1,1,3,3-tetramethyl-5-indane) methanol 
• 69277-63-0 5-(1-Bromo-ethyl)-1,1,3,3-tetramethyl-indan 
• 6287-86-1 p-ethoxycarbonylbenzaldehyde 
• 69251-31-6 <1-(1,1,3,3-tetramethyl-5-indanyl)ethyl>-triphenylphosphonium bromide 

Relevant academic research and scientific papers

Stilbene derivatives

This invention is directed to 5,6,7,8-tetrahydro-naphthyl or indanyl stilbene derivatives which are useful as tumor inhibiting agents, in the treatment of neoplasms, dermatological conditions and rheumatic illnesses.

Arotinoids, a new class of highly active retinoids

The synthesis and biological activity of new aromatic retinoids are reported. The most active ones belong to a chemical class of compounds, which we have termed 'arotinoids'. For the compound p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl)]-benzoic acid ethyl ester, a therapeutic potency in the antipapilloma test was found which exceeds that of retinoic acid by a factor of 8000, while the concurrently observed toxic hypervitaminosis A effects are only increased by a factor of 800. The structural relationship of the arotinoids with retinoic acid is demonstrated; the arotinoids contain the retinoic acid carbon skeleton in a fixed cisoid geometric conformation.