17610-14-9

Usage

Uses

Used in Fragrance Industry:
1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone is used as a base note in perfume compositions for its ability to enhance and prolong the overall fragrance profile.
Used in Aromatherapy and Wellness Products:
1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone is used as a calming and stress-reducing agent in aromatherapy and wellness products due to its soothing effects.

Upstream product

• 4834-33-7 1,1,3,3-tetramethylindan 
• 75-36-5 acetyl chloride 
• 66564-05-4 5-tert-butyl-2,3-dihydro-1,1,3,3-tetramethyl-1H-indene 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 4132-49-4 p-tert.-Butyl-cumol 
• 98-82-8 Isopropylbenzene 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 

Downstream Products

• 69251-31-6 <1-(1,1,3,3-tetramethyl-5-indanyl)ethyl>-triphenylphosphonium bromide 
• 71441-27-5 4'-[(E)-2-(1,1,3,3-tetramethyl-5-indanyl)propenyl]-acetophenone 
• 69251-08-7 2E-4E-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trienoic acid 
• 71441-07-1 p-<(E)-2-(1,1,3,3-tetramethyl-5-indanyl)-propenyl>-benzoic acid ethylester 

Relevant academic research and scientific papers

Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors

Retinoic acid receptor (RAR)-related orphan receptors (RORs) regulate a variety of physiological processes, including hepatic gluconeogenesis, lipid metabolism, circadian rhythm and immune function. The RAR agonist: all-trans retinoic acid was reported to be an RORβ inverse agonist, but no information is available regarding ROR activity of its synthetic analogue Am580. Therefore, we screened Am580 and some related tetramethyltetrahydronaphthalene derivatives and carried out structural development studies, including substitution of carbon atoms with silicon, with the aim of creating a potent ROR transcriptional inhibitor. The phenyl amide disila compound 22 showed the most potent ROR-inhibitory activity among the compounds examined. Its activity towards RORα, RORβ and RORγ was increased compared to that of Am580. The IC50 values for RORα, RORβ and RORγ are 1.3, >10 and 4.5 μM, respectively.

Disubstituted chalcone oximes as selective agonists of RAR retinoid receptors

Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RARγ agonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.