71516-49-9Relevant academic research and scientific papers
Aminopolycarboxylic acids and derivatives thereof
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, (2008/06/13)
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula I wherein n and m are 2, 3 or 4; and A, X, R1 and Z are as defined in the specification.
Aminopolycarboxylic acids and derivatives thereof
-
, (2008/06/13)
There are provided chelating agents particularly useful for the preparations of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula X--CHR1 --NZ--(CHR1)n --A--(CHR1)m --NZ--CHR1 --X wherein (each of the groups Z is a group --CHR1 X or the groups Z together are a group --(CHR1)q --A'--(CHR1)r --, where A' is an oxygen or sulphur atom or a group --N--Y; A is a group --N--Y or A--(CHR1)m -- represents a carbon-nitrogen bond or, when the groups Z together are a group --(CHR1)q --A'--(CHR1)r --, A may also represent an oxygen or sulphur atom; each Y, which may be the same or different, is a group --(CHR1)p --N(CHR1 X)2 or a group --CHR1 X; each X, which may be the same or different, is a carboxyl group or a derivative thereof or a group R1 ; each R1, which may be the same or different, is a hydrogen atom, a hydroxyalkyl group or an optionally hydroxylated alkoxy or alkoxyalkyl group; n, m, p, q and r are each 2, 3 or 4; with the provisos that at least two nitrogens carry a --CHR1 X moiety wherein X is a carboxyl group or a derivative thereof, that each --CHR1 X moiety is other than a methyl group, and that unless A' is oxygen or sulphur or A is N--(CHR1)p --N(CHR1 X)2 at least one R1 is other than hydrogen) and salts thereof.
Synthesis and Use of 7-Substituted Norbornadienes for the Preparation of Prostaglandins and Prostanoids
Baxter, Anthony D.,Binns, Falmai,Javed, Tariq,Roberts, Stanley M.,Sadler, Peter,et al.
, p. 889 - 900 (2007/10/02)
Syntheses of 7-substituted norbornadienes from 7-t-butoxy- and 7-halogeno-norbornadienes are described.Rearrangement of the products in the presence of peracetic acid gives bicyclic aldehydes (2) in equilibrium with enol ethers (3) which are hydrolysed to hydroxycyclopentenylacetaldehydes (4), and converted into key intermediates for the synthesis of prostaglandins and their analogues.Syntheses of prostaglandin J analogues with n-hexyl and phenyl groups replacing the ο-side-chain are described.
