71550-80-6

Usage

InChI:InChI=1/C9H16O3/c1-12-9(11)8-5-3-2-4-7(8)6-10/h7-8,10H,2-6H2,1H3/t7-,8+/m1/s1

Upstream product

• 7719-08-6 trans-1,2-cyclohexanedicarboxylic acid,monomethyl ester 
• 13169-51-2 2-(chloromethyl)benzamide 
• 87-41-2 2-benzofuran-1(3H)-one 
• 67-56-1 methanol 
• 93379-40-9 2-hydroxymethyl-cyclohexanecarboxylic acid 
• 55741-02-1 o-(N,N-Diethyl-aminomethyl)-benzoesaeure 

Relevant academic research and scientific papers

Process for making perhydroindole-2-carbonxylic acid

A process for the asymmetric preparation of a compound of the formula STR1 wherein the hydrogen at 3a and 7a are of cis or trans configuration and their non-toxic, pharmaceutically acceptable acid addition salts comprising submitting a compound of the formula STR2 to a Hoffman reaction and reacting the resulting product with formaldehyde in the presence of cyanide ions and acid halide of benzoic acid or an aliphatic carboxylic acid of 1 to 5 carbon atoms to obtain a compound of the formula STR3 wherein R is acyl of benzoic acid or aliphatic carboxylic acid of 1 to 5 carbon atoms, cyclizing the latter to form a compound of the formula STR4 selectively hydrolyzing the latter with a dilute aqueous mineral acid to obtain a compound of the formula STR5 subjecting the latter to hydrolysis with a concentrated aqueous mineral acid to form the acid addition salt of a compound of claim 1 and optionally forming the free base.

Thioalkanoylalkanoic acid compounds

Thioalkanoylalkanoic acid compounds and salts thereof having the formula STR1 wherein R 1, R 2, R 3 and R 4 each is hydrogen or lower alkyl;R 5 is hydrogen, lower alkanoyl, benzoyl or STR2 A and B each is hydrogen or join together as a polymethylene chain --(CH 2) n -- to complete a 4-, 5- or 6- membered cycloalkyl group, and m is 0 or 1,are angiotensin converting enzyme inhibitors and are useful as hypotensive agents.