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Usage

Uses

Used in Fragrance Industry:
1,2-Cyclohexanedicarboxylic acid, monomethyl ester is used as a key ingredient in the production of fragrances for its ability to contribute to the overall scent profile of various products.
Used in Plasticizer Industry:
In the manufacturing of polymers and resins, 1,2-Cyclohexanedicarboxylic acid, monomethyl ester is used as a plasticizer to enhance the flexibility and workability of these materials, making them more suitable for a wide range of applications.
Used in Pharmaceutical Industry:
1,2-Cyclohexanedicarboxylic acid, monomethyl ester is utilized in the production of pharmaceuticals, where it plays a crucial role in the synthesis of various medicinal compounds, contributing to their efficacy and stability.
Used in Agricultural Chemical Industry:
1,2-Cyclohexanedicarboxylic acid, monomethyl ester is also employed in the production of agricultural chemicals, where it aids in the development of effective and stable formulations for crop protection and enhancement.
Environmental Considerations:
1,2-Cyclohexanedicarboxylic acid, monomethyl ester is considered to be relatively low in toxicity, with biodegradable properties and low potential for bioaccumulation in the environment, making it a more sustainable choice for industrial applications.
Safety Precautions:
While it is relatively low in toxicity, prolonged exposure to high concentrations of 1,2-Cyclohexanedicarboxylic acid, monomethyl ester may cause irritation to the eyes and skin. Therefore, appropriate safety measures should be taken during its handling and use.

Upstream product

• 4336-20-3 dimethyl 1,2-cyclohexanedicarboxylate 
• 74-88-4 methyl iodide 
• 4376-18-5 Monomethyl phthalate 
• 67-56-1 methanol 
• 18448-47-0 methyl cyclohex-1-ene-1-carboxylate 
• 124-38-9 carbon dioxide 
• 93603-11-3 1-methyl hydrogen 1,2-cis-1,2-cyclohex-4-ene dicarboxylate 
• 85-42-7 trans-1,2-cyclohexanedicarboxylic anhydride 
• 2484-60-8 cyclohexane-1,2-dicarboxylic acid monomethyl ester 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 110-83-8 cyclohexene 
• 32166-29-3 8,8-dichlorobicyclo[4.2.0]octan-7-one 
• 64109-98-4 methyl trans-2-formylcyclohexane-1-carboxylate 
• 31139-02-3 (+/-)-trans-cyclohex-4-ene-1,2-dicarboxylic acid monomethyl ester 

Downstream Products

• 1268629-29-3 methyl 2-(3-phenylpropylcarbamoyl)-cyclohexanecarboxylate 
• 1234381-55-5 (1S,2R)-cis-1-(4-bromophenyl) 2-methyl cyclohexane-1,2-dicarboxylate 
• 18448-47-0 methyl cyclohex-1-ene-1-carboxylate 
• 25662-37-7 methyl cyclohex-2-en-1-carboxylate 
• 64109-98-4 methyl trans-2-formylcyclohexane-1-carboxylate 
• 2484-60-8 (1S*,2S*)-2-(methoxycarbonyl)cyclohexane-1-carboxylic acid 
• 88335-92-6 (1S,2R)-2-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 54053-76-8 cis-3-thiabicyclo<3.4.0>nonane 
• 59461-66-4 cis-cyclohexane-1,2-diyldimethyl ditosylate 

Relevant academic research and scientific papers

Photocatalyzed, β-Selective Hydrocarboxylation of α,β-Unsaturated Esters with CO2under Flow for β-Lactone Synthesis

A photocatalyzed, β-selective hydrocarboxylation of α,β-unsaturated esters employing CO2 radical anion generated under flow conditions was developed. A range of substrates bearing a variety of functional groups were tolerated, demonstrating chemoselectivity. A series of quaternary carboxylic acids were obtained from sterically demanding β,β-disubstituted alkenes including those derived from natural products. Mechanistic studies support a Giese-type CO2 radical anion conjugate addition followed by hydrogen atom transfer from (TMS)3SiH as the principal reaction pathway. Finally, a telescoped process involving the described β-carboxylation followed by a α-bromination/β-lactonization sequence provides a strategy for β-lactone synthesis.

Synthesis method of trans 1 and 2 - cyclohexane dicarboxylic acid monomethylester

The invention provides a synthesis method of trans 1 and 2 - cyclohexane dicarboxylic acid monomethylester, and belongs to the field of organic synthesis. The trans 1-2 -cyclohexane dicarboxylic acid monomethylester synthesis method comprises the following steps: trans-cyclohexane -1 and 2 -dicarboxylic acid anhydride. The methanol and solvent is added to the reaction vessel, stirred and purified to obtain the target product trans 1, 2 - cyclohexanedicarboxylate, wherein the solvent is any one or more of tetrahydrofuran, 2 - methyltetrahydrofuran, benzene, toluene, methylene chloride, chloroform, ethyl acetate, methyl acetate or diethyl ether. Since a specific solvent is selected for the reaction solvent, racemization does not occur in the process of synthesizing trans 1 and 2 - cyclohexane dicarboxylic acid monomethyl ester, and the trans ee and 1 cyclohexane dicarboxylic acid monomethyl ester with higher 2 - value can be finally obtained.

Synthesis of trans-fused octahydroisoindole-1-carboxylic acids

trans-Fused octahydroisoindole-1-carboxylic acids are bicyclic proline analogues of potential interest in the search for new drugs. Within this work, the trans-fused octahydroisoindole system has been constructed using methyl trans-2-(hydroxymethyl)cycloh

HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS

A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.

Monomeric and Dimeric 9-O Anthraquinone and Phenanthryl Derivatives of Cinchona Alkaloids as Chiral Solvating Agents for the NMR Enantiodiscrimination of Chiral Hemiesters

Mono- and bis-alkaloid chiral auxiliaries with anthraquinone or phenanthryl cores were probed as chiral solvating agents (CSAs) for the enantiodiscrimination of chiral cyclic hemiesters. The dimeric anthraquinone derivative and the monomeric phenanthryl o

PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS

A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.

Synthetic studies on CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-wittig rearrangement

An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation, intramolecular conjugate displacement, and [2,3]-Wittig rearrangement. A variant of the [2,3]-Wittig rearrangement was developed.

The immobilisation of chiral organocatalysts on magnetic nanoparticles: The support particle cannot always be considered inert

A systematic study concerning the immobilisation onto magnetic nanoparticles of three useful classes of chiral organocatalyst which rely on a confluence of weak, easily perturbed van der Waals and hydrogen bonding interactions to promote enantioselective

Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase

Structure-activity relationships of cycloalkylamide compounds as inhibitors of human sEH were investigated. When the left side of amide function was modified by a variety of cycloalkanes, at least a C6 like cyclohexane was necessary to yield reasonable inhibition potency on the target enzyme. In compounds with a smaller cycloalkane or with a polar group on the left side of amide function, no inhibition was observed. On the other hand, increased hydrophobicity dramatically improved inhibition potency. Especially, a tetrahydronaphthalene (20) effectively increased the potency. When a series of alkyl or aryl derivatives of cycloalkylamide were investigated to continuously optimize the right side of the amide pharmacophore, a benzyl moiety functionalized with a polar group produced highly potent inhibition. A nonsubstituted benzyl, alkyl, aryl, or biaryl structure present on the right side of the cycloalkylamide function induced a big decrease in inhibition potency. Also, the resulting potent cycloalkylamide (32) showed reasonable physical properties.

A new structural motif for bifunctional bronsted acid/base organocatalysis

"Chemical equation presented" Naturally synthetic: Acid/base catalyst (S)-I can be used in highly enantioselective alcoholytic desymmetrizations of meso anhydrides. For example, the methanolysis of cyclobutane anhydride deriva-tive 2 gave hemiester 3 in 99:1 e.r. (see scheme). Ester 3 was used in a short enantioselective synthesis of (+ )-grandisol.