71739-67-8Relevant academic research and scientific papers
First total synthesis of isoquinolinone alkaloid marinamide and its methyl ester
Feng, Cheng-Liang,Zhang, Shu-Guang,Chen, Jun-Qing,Cai, Jin,Ji, Min
, p. 767 - 769 (2013)
The first total synthesis of isoquinolinone alkaloid marinamide 1 and its methyl ester 2 was described. The key steps involved a regioselective Friedel-Crafts reaction of 1-benzyl-1H-pyrrole to form the intermediate 8.
Total synthesis of a novel isoquinolinone alkaloid marinamide and its methyl ester
Zhang, Shuguang,Feng, Chengliang,Cai, Jin,Chen, Junqing,Ji, Min
, p. 291 - 293 (2013/07/27)
A naturally occurring isoquinolinone alkaloid marinamide and its methyl ester were synthesised from phthalic anhydride over eight steps in 46% and 52% overall yield. The key intermediate methyl 2-(1-benzyl-1H-pyrrole-2-carbonyl) benzoate was synthesised from the acid chloride of mono methyl phthalate and 1-benzyl-1H-pyrrole catalysed by Zinc oxide under solvent-free conditions at room temperature.
Solvent free synthesis of 2-acylpyrroles and its derivatives catalysed by reuseable zinc oxide
Zhang, Shuguang,Feng, Chengliang,Cai, Jin,Chen, Junqing,Hu, Huayou,Ji, Min
, p. 480 - 482 (2013/09/12)
A highly efficient procedure for preparing 2-acylpyrroles and its derivatives is described. The products were obtained through regioselective Friedel-Crafts reactions of pyrroles and its derivatives with alkyl or aryl acid chlorides catalysed by zinc oxide under solvent-free conditions. This method has the advantages of green chemistry, operational simplicity, solvent-free conditions, and recoverable catalyst.
