499796-71-3

Basic information

• Product Name: 2-Pyridinecarboxamide,5-fluoro-(9CI)
• Synonyms: 2-Pyridinecarboxamide,5-fluoro-(9CI);5-fluoropicolinaMide;5-Fluoro-2-pyridinecarboxaMide;2-PyridinecarboxaMide, 5-fluoro
• CAS NO: 499796-71-3
• Molecular Formula: C₆H₅FN₂O
• Molecular Weight: 140.117
• EINECS: 201-525-2
• Product Categories: AMIDE;PYRIDINE
• Mol File: 499796-71-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 256.7 °C at 760 mmHg
• Flash Point: 109 °C
• Appearance: /
• Density: 1.327 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 15.00±0.50(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxamide,5-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide,5-fluoro-(9CI)(499796-71-3)
• EPA Substance Registry System: 2-Pyridinecarboxamide,5-fluoro-(9CI)(499796-71-3)

Safety Data

• Hazardous Substances Data: 499796-71-3(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxamide, 5-fluoro-(9CI) is a chemical compound with the molecular formula C6H5FN2O. It is a derivative of 2-pyridinecarboxamide, and the addition of a fluorine atom in the 5-position of the pyridine ring gives it its unique properties. 2-Pyridinecarboxamide,5-fluoro-(9CI) is of interest in pharmaceutical and medicinal chemistry due to its potential as a drug candidate. Its specific biological and pharmacological activities have not been widely studied, but its structural resemblance to other known bioactive molecules suggests that it may have potential as a therapeutic agent. Further research is needed to fully understand and harness the potential of 2-pyridinecarboxamide, 5-fluoro-(9CI) for various applications in the medical and pharmaceutical fields.

Upstream product

• 55338-73-3 5-amino-2-cyanopyridine 
• 717871-83-5 5-fluoropicolinoyl chloride 
• 107504-08-5 5-fluoropicolinic acid 
• 327056-62-2 5-fluoropicolinonitrile 

Downstream Products

• 107504-08-5 5-fluoropicolinic acid 

Relevant articles and documents

An improved Balz-Schiemann reaction enabled by ionic liquids and continuous processing

A Balz-Schiemann reaction was developed to convert 2-cyano-5-aminopyridine to 2-cyano-5-fluoropyridine. The use of an ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate, BMIMBF4) as a solvent was found to be critical in achieving high assay yields and high selectivity for the fluorination vs. protonation. A process was developed to recycle and reuse the ionic liquid enabling its cost-effective use as a solvent. Finally, the optimal conditions were demonstrated under as a continuous process to address process safety risks associated with diazonium intermediates and the product was used to access a key intermediate in the synthesis of β-amyloid cleaving enzyme 1 inhibitor, verubecestat.

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Efficient and substrate-specific hydration of nitriles to amides in water by using a CeO2 catalyst

CeO2 acted as a reusable and effective catalyst for the hydration of various nitriles to amides in water under neutral conditions at low temperature (30-100 °C). CeO2 showed notable substrate specificity for nitriles that have a heteroatom adjacent to the α-carbon atom of the CN group (see scheme).