7182-43-6

Basic information

• Product Name: 4-(4-HYDROXYPHENYL)-4-OXOBUTANENITRILE
• Synonyms: 4-(4-HYDROXYPHENYL)-4-OXOBUTANENITRILE;4-(4-hydroxy-phenyl)-4-oxo-butyronitrile
• CAS NO: 7182-43-6
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 7182-43-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 423.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• PKA: 7.90±0.15(Predicted)
• CAS DataBase Reference: 4-(4-HYDROXYPHENYL)-4-OXOBUTANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-HYDROXYPHENYL)-4-OXOBUTANENITRILE(7182-43-6)
• EPA Substance Registry System: 4-(4-HYDROXYPHENYL)-4-OXOBUTANENITRILE(7182-43-6)

Safety Data

• Hazardous Substances Data: 7182-43-6(Hazardous Substances Data)

Usage

General Description

4-(4-Hydroxyphenyl)-4-oxobutanenitrile is a chemical compound with the molecular formula C10H9NO2. It is a nitrile derivative of 4-hydroxyphenyl-4-oxobutane, and it is commonly used in organic synthesis and pharmaceutical research. 4-(4-HYDROXYPHENYL)-4-OXOBUTANENITRILE has potential biological and pharmacological activities and can be used as a building block in the development of various drugs and medicinal products. It is important to handle this chemical with caution as it may have potential health hazards if not properly managed and used in controlled environments.

Upstream product

• 55234-56-5 4-(4-methoxy-phenyl)-4-oxo-butyronitrile 
• 151-50-8 potassium cyanide 
• 856983-89-6 4-(4-methoxy-phenyl)-4-oxo-butyric acid amide 
• 100-66-3 methoxybenzene 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 

Downstream Products

• 56872-39-0 3-(4-hydroxybenzoyl)propionic acid 

Relevant articles and documents

(Phenylmethoxy)phenyl Derivatives of Ω-Oxo- and Ω-Tetrazolylalkanoic Acids and Related Tetrazoles. Synthesis and Evaluation as Leukotriene D4 Receptor Antagonists

Two series of (phenylmethoxy)phenyl compounds derived from the structure of LY163443 were synthesized and evaluated as leukotriene D4 receptor antagonists.In the Ω--Ω-oxoalkanoic acid series, 5-phenyl>-3,3-dimethyl-5-oxopentanoic acid (8) was the most potent antagonist of LTD4-induced contractions of guinea pig ileum (pKB of 7.60) and LTD4 pressor response in pithed rats (ED50 of 1.4 mg/kg iv).Replacing the carboxylic acid function with 5-tetrazole gave slightly more potent compounds.Inthe Ω-alkyl>tetrazolyl>alkanoic acid series, replacing the carboxylic acid with 5-tetrazole gave compounds that were equally effective in the guinea pig ileum but more potent in vivo against the LTD4 pressor response in rat.The pKB value in the guinea pig ileum for 1--2H-tetrazol-5-yl>methyl>phenoxy>methyl>phenyl>ethanone (25) was 7.87 and the ED50 for antagonism of the LTD4 pressor response was 4.0 mg/kg iv.The sodium salts of 8 (9) and 25(26) given by the iv route of administration antagonized LTD4-induced cardiovascular alterations in anesthetized rat and LTD4-induced bronchoconstriction in guinea pig in a dose-dependent manner.Oral activity was also demonstrated against the LTD4-induced bronchoconstriction in guinea pig.