7182-43-6 Usage
Uses
Used in Pharmaceutical Research:
4-(4-Hydroxyphenyl)-4-oxobutanenitrile is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(4-Hydroxyphenyl)-4-oxobutanenitrile is utilized as a versatile building block for the creation of a wide range of organic molecules. Its reactivity and functional groups make it suitable for various chemical reactions, leading to the formation of complex organic compounds.
Used in Drug Development:
4-(4-Hydroxyphenyl)-4-oxobutanenitrile is employed as a precursor in the development of new drugs, particularly those targeting specific biological pathways or diseases. Its potential biological and pharmacological activities make it a valuable component in the design and synthesis of innovative medicinal products.
Used in Medicinal Chemistry:
In medicinal chemistry, 4-(4-Hydroxyphenyl)-4-oxobutanenitrile is used as a structural element in the design of novel compounds with potential therapeutic benefits. Its incorporation into drug candidates can enhance their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Chemical Research:
4-(4-Hydroxyphenyl)-4-oxobutanenitrile is also used in chemical research to study the properties and reactivity of nitriles and related functional groups. This knowledge can contribute to the advancement of synthetic methods and the development of new chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 7182-43-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,8 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7182-43:
(6*7)+(5*1)+(4*8)+(3*2)+(2*4)+(1*3)=96
96 % 10 = 6
So 7182-43-6 is a valid CAS Registry Number.
7182-43-6Relevant academic research and scientific papers
(Phenylmethoxy)phenyl Derivatives of Ω-Oxo- and Ω-Tetrazolylalkanoic Acids and Related Tetrazoles. Synthesis and Evaluation as Leukotriene D4 Receptor Antagonists
Dillard, Robert D.,Hahn, Richard A.,McCullough, Doris,Carr, F. Patrick,Rinkema, Lynn E.,et al.
, p. 2768 - 2778 (2007/10/02)
Two series of (phenylmethoxy)phenyl compounds derived from the structure of LY163443 were synthesized and evaluated as leukotriene D4 receptor antagonists.In the Ω--Ω-oxoalkanoic acid series, 5-phenyl>-3,3-dimethyl-5-oxopentanoic acid (8) was the most potent antagonist of LTD4-induced contractions of guinea pig ileum (pKB of 7.60) and LTD4 pressor response in pithed rats (ED50 of 1.4 mg/kg iv).Replacing the carboxylic acid function with 5-tetrazole gave slightly more potent compounds.Inthe Ω-alkyl>tetrazolyl>alkanoic acid series, replacing the carboxylic acid with 5-tetrazole gave compounds that were equally effective in the guinea pig ileum but more potent in vivo against the LTD4 pressor response in rat.The pKB value in the guinea pig ileum for 1--2H-tetrazol-5-yl>methyl>phenoxy>methyl>phenyl>ethanone (25) was 7.87 and the ED50 for antagonism of the LTD4 pressor response was 4.0 mg/kg iv.The sodium salts of 8 (9) and 25(26) given by the iv route of administration antagonized LTD4-induced cardiovascular alterations in anesthetized rat and LTD4-induced bronchoconstriction in guinea pig in a dose-dependent manner.Oral activity was also demonstrated against the LTD4-induced bronchoconstriction in guinea pig.
