7189-04-0

Basic information

• Product Name: 1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-METHYL-1,3-DIPHENYL-, ETHYL ESTER
• Synonyms: 1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-METHYL-1,3-DIPHENYL-, ETHYL ESTER;ETHYL 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLATE;5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 7189-04-0
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.36
• Mol File: 7189-04-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 105-106℃
• Boiling Point: 457.9 °C at 760 mmHg
• Flash Point: 230.8 °C
• Appearance: /
• Density: 1.13
• CAS DataBase Reference: 1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-METHYL-1,3-DIPHENYL-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-METHYL-1,3-DIPHENYL-, ETHYL ESTER(7189-04-0)
• EPA Substance Registry System: 1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-METHYL-1,3-DIPHENYL-, ETHYL ESTER(7189-04-0)

Safety Data

• Hazardous Substances Data: 7189-04-0(Hazardous Substances Data)

Usage

General Description

The chemical 1H-pyrazole-4-carboxylic acid, 5-methyl-1,3-diphenyl-, ethyl ester is an ethyl ester derivative of pyrazole-4-carboxylic acid, 5-methyl-1,3-diphenyl. It is a compound that contains a pyrazole ring and two phenyl rings, with a methyl group and an ethyl ester group attached to the pyrazole ring. This chemical may have potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. Its specific properties, uses, and potential effects on health and the environment would depend on its exact composition and application.

Upstream product

• 4341-76-8 Ethyl 2-butynoate 
• 588-64-7 benzaldehyde phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
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• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 64-17-5 ethanol 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 60-29-7 diethyl ether 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 

Downstream Products

• 191419-22-4 ethyl 5-(bromomethyl)-1,3-diphenyl-1H-pyrazole-4-carboxylate 
• 40697-58-3 5-methyl-1,3-diphenyl-1H-pyrazole-4-carbohydrazide 
• 191418-74-3 5-Hydroxythiocarbamoyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 191419-23-5 5-(Hydroxyimino-methyl)-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 191418-93-6 5-cyano-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 165676-63-1 1,3-diphenyl-1H-pyrazole-4,5-dicarboxylic acid 
• 193765-66-1 4,5-diphenoxycarbonyloxymethyl-1,3-diphenylpyrazole 
• 193765-65-0 5-Hydroxymethyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 188619-15-0 4,5-Bis-chloromethyl-1,3-diphenyl-1H-pyrazole 

Relevant articles and documents

A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

Abstract: A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, 1H and 13C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.

Novel 5-functionalized-pyrazoles: Synthesis, characterization and pharmacological screening

In the present study a series of O-substituted pyrazoles 7(a-f) and N-substituted pyrazoles 9(a-f) were synthesized via phase-transfer catalyzed reaction of ethyl 5-(bromomethyl)-1,3-diphenyl-1H-pyrazole-4-carboxylate 5 with various oxygen and nitrogen containing compounds in presence of tetrabutylammonium bromide (TBAB) in THF. The compound 5 was obtained by the efficient bromination with N-bromosuccinimide (NBS) in presence of a catalytic amount of azoiso-bis-butyro nitrile (AIBN) in refluxing CCl4. The synthesized compounds were evaluated for their in vitro antimicrobial and antidiabetic activity and were compared with standard drugs. Among the synthesized compounds, compound 9b emerged as an excellent antimicrobial and antidiabetic agent. Newly synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, 13C NMR and LC-MS) methods.

PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES

The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.