15409-48-0

Basic information

• Product Name: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: VITAS-BB TBB000142;CHEMBRDG-BB 4400208;ART-CHEM-BB B000126;5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID;AKOS B000126;5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid(SALTDATA: FREE)
• CAS NO: 15409-48-0
• Molecular Formula: C₁₇H₁₄N₂O₂
• Molecular Weight: 278.31
• Mol File: 15409-48-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 196°C
• Boiling Point: 447.5°C at 760 mmHg
• Flash Point: 224.4°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 8.59E-09mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(15409-48-0)
• EPA Substance Registry System: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(15409-48-0)

Safety Data

• Hazardous Substances Data: 15409-48-0(Hazardous Substances Data)

Usage

General Description

5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid is a chemical compound that belongs to the class of pyrazole derivatives. It is a carboxylic acid that contains a pyrazole ring with a methyl group and two phenyl groups attached to it. 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID has potential pharmacological and biological activities and is used in various research and development studies. It is also used in the synthesis of other organic compounds and materials. The chemical structure of 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid makes it suitable for various applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C17H14N2O2/c1-12-15(17(20)21)16(13-8-4-2-5-9-13)18-19(12)14-10-6-3-7-11-14/h2-11H,1H3,(H,20,21)

Upstream product

• 7189-04-0 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 100-63-0 phenylhydrazine 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 854901-03-4 5-methyl-1,3-diphenyl-1H-pyrazole-4-carbonitrile 
• 588-64-7 benzaldehyde phenylhydrazone 
• 854699-23-3 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid amide 

Downstream Products

• 7188-89-8 5-methyl-1,3-diphenyl-1H-pyrazole 
• 125103-49-3 (5-Methyl-1,3-diphenyl-1H-pyrazol-4-yl)-morpholin-4-yl-methanone 
• 125103-43-7 N-benzyl-N,5-dimethyl-1,3-diphenyl-1H-pyrazole-4-carboxamide 
• 125103-46-0 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid dipropylamide 
• 125103-45-9 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid diisopropylamide 
• 125103-47-1 N-benzyl-5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxamide 
• 125103-48-2 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid (3-methyl-butyl)-amide 
• 125103-50-6 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid butylamide 
• 125103-42-6 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-ethyl)-amide 
• 125103-44-8 5-Methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid tert-butylamide 
• 124-38-9 carbon dioxide 
• 857058-17-4 1,3-diphenyl-5-methylpyrazole-4-carboxylic chloride 

Relevant articles and documents

A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

Abstract: A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, 1H and 13C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.

The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are