7189-05-1

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1,3-diphenyl-1H-pyrazol-4-yl)ethan-1-one is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows for the creation of a range of medicinal compounds, contributing to the development of novel treatments for different health conditions.
Used in Dye and Pigment Production:
In the chemical industry, 1-(1,3-diphenyl-1H-pyrazol-4-yl)ethan-1-one is utilized as a vital component in the production of dyes and pigments. Its chemical properties make it suitable for creating a diverse array of colorants used in various applications, from textiles to plastics.
Used in Chemical Research:
Diphenylpyrazol is also employed as a valuable reagent in chemical research due to its stability and purity. It aids in the advancement of scientific knowledge and the development of new chemical processes and products.
Used in Drug Discovery and Development:
1-(1,3-diphenyl-1H-pyrazol-4-yl)ethan-1-one has been studied for its potential biological and pharmacological activities. It shows promise as a lead compound in drug discovery and development, potentially leading to the creation of new therapeutic agents to address various medical needs.

Upstream product

• 820-69-9 (E)-hex-3-ene-2,5-dione 
• 231289-36-4 C,N-Diphenylnitrilimine 
• 27871-55-2 3,4-diacetylhex-3-ene-2,5-dione 
• 1008-79-3 1-phenyl-1H-pyrazol-3-ol 
• 7409-28-1 1-(3-hydroxy-1-phenyl-1H-pyrazol-4-yl)ethan-1-one 
• 7409-21-4 1-phenyl-1H-pyrazol-3-yl acetate 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 59068-35-8 5-benzoyl-4-methyl-2-phenylpyrimidine 
• 126685-80-1 5-Benzoyl-4-methyl-2-methylthiopyrimidine 
• 1354413-52-7 4-acetyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

The use of enaminones and enamines as effective synthons for MSA-catalyzed regioselective synthesis of 1,3,4-tri- And 1,3,4,5-tetrasubstituted pyrazoles

In the present work, an efficient regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles via a methanesulfonic acid (MSA)-catalyzed reaction of hydrazones with enaminones or enamines is reported. Mechanistically, the formation of the title compounds involves the [2+3] cycloaddition of hydrazones with enaminones or enamines followed by aromatization with acid and oxygen. This convenient method under mild conditions with various hydrazones, enaminones, and enamines was well-tolerated to afford products in good to excellent yields. Compared with the literature methods, this strategy has advantages such as materials that are available economically, metal-free catalysis, excellent regioselectivity, and high efficiency.

Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalysed cross-coupling reactions

An efficient synthetic route to construct ortho-substituted 1-phenyl-1H-pyrazole-4-carboxaldehydes and the corresponding ethanones starting from 1-phenyl-1H-pyrazol-3-ol is described. Carbon-carbon bond-forming Pd-catalysed cross-coupling reactions were applied for the functionalisation of the intermediate pyrazole triflates. Detailed NMR spectroscopic investigations were undertaken with all obtained products. ARKAT-USA, Inc.

1,3-Dipolar Cycloadditions of Aryl Nitrilimines to Electron-poor Alkenes

The 1,3-dipolar cycloadditions of aryl nitrilimines to 1,2-diacetylethylene gave along with 1,2-diaryl-4,5-diacetyl-4,5-dihydropyrazoles 5 and the corresponding dehydrogenated pyrazoles 6, the unexpected 1,3-diaryl-4-acetylpyrazoles 7.As for tetrasubstituted alkenes, whereas 1,2-diacetyl-1,2-dicarbethoxyethylene gave a stable cycloadduct 8, 1,2,3,4-tetraacetylethylene yielded a mixture of pyrazoles 6 and 7.