719-82-4

Basic information

• Product Name: 2-(4-fluorophenyl)-2-phenyl-acetonitrile
• Synonyms: 2-(4-fluorophenyl)-2-phenyl-acetonitrile;Nsc23818
• CAS NO: 719-82-4
• Molecular Formula: C₁₄H₁₀FN
• Molecular Weight: 211.23
• Mol File: 719-82-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 39-41 °C
• Boiling Point: 313°C at 760 mmHg
• Flash Point: 134.2°C
• Appearance: /
• Density: 1.149g/cm³
• Vapor Pressure: 0.000511mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 2-(4-fluorophenyl)-2-phenyl-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2-phenyl-acetonitrile(719-82-4)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2-phenyl-acetonitrile(719-82-4)

Safety Data

• Hazardous Substances Data: 719-82-4(Hazardous Substances Data)

Usage

Uses

2-(4-Fluorophenyl)-2-phenylacetonitrile is used as a reagent in the synthesis of unsymmetric triarylacetonitriles via palladium-catalyzed sequential arylations from chloroacetonitrile and further conversion to tri- and tetraarylmethanes.

InChI:InChI=1/C14H10FN/c15-13-8-6-12(7-9-13)14(10-16)11-4-2-1-3-5-11/h1-9,14H

Upstream product

• 462-06-6 fluorobenzene 
• 5798-79-8 bromo-phenyl-acetonitrile 
• 71-43-2 benzene 
• 459-22-3 4-fluorophenylacetonitrile 
• 133721-87-6 2-(4-fluorophenyl)-2-hydroxyacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 149099-27-4 4-fluorobenzhydrol 
• 140-29-4 phenylacetonitrile 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 98-80-6 phenylboronic acid 
• 88675-31-4 2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one 
• 1582-01-0 4-fluorophenyl tosylate 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 

Downstream Products

• 2927-79-9 2-(4-fluoro-phenyl)-2-phenyl-ethylamine 
• 345-83-5 4-fluorobenzophenone 
• 324008-27-7 2-(4-fluoro-phenyl)-2-phenyl-thioacetamide 
• 324008-32-4 2-(2-{2-[(4-fluoro-phenyl)-phenyl-methyl]-thiazol-4-yl}-ethyl)-isoindole-1,3-dione 

Relevant articles and documents

Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes

A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reacti

BF3·OEt2-mediated [1,2]-aryl shift: Synthesis of functionalized α-arylnitriles via the bromination/cyanation/deformylation of substituted deoxybenzoin

A new sequential, tandem synthesis of functionalized α-arylnitriles via the bromination/cyanation/deformylation of substituted deoxybenzoin has developed. CuBr2-promoted bromination of substituted deoxybenzoins gives 2-bromo-2-arylacetophenne 3. The cyanation of 3 with sodium cyanide (NaCN) generates epoxynitrile. Then, a treatment of epoxynitrile with BF3·OEt2 results in the formation of functionalized α-arylnitriles 4 via a 1,2-aryl shift.

Zn(OTf)2 - Catalyzed direct cyanation of benzylic alcohols - A novel synthesis of α-aryl nitriles

This work demonstrates an efficient method to prepare α-aryl nitriles by direct cyanation of benzylic alcohol with TMSCN in the presence of a catalytic amount of Zn(OTf)2 under heating condition. A variety of benzylic alcohols can be converted into the corresponding α-aryl nitriles in good to excellent yields. 2012 Elsevier Ltd. All rights reserved.