72019-17-1Relevant academic research and scientific papers
A β - hydroxyalkanephosphonic ester derivatives
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Paragraph 0055-0059, (2017/08/31)
The invention discloses a preparation method of beta-hydroxyphosphonate derivatives. The preparation method comprises that an arylethene derivative, a phosphorus reagent and manganese acetate are dissolved in a solvent and the solution undergoes a reactio
Mn(OAc)3-mediated synthesis of β-hydroxyphosphonates from P(O)-H compounds and alkenes
Gao, Yuzhen,Wu, Ju,Xu, Jian,Zhang, Pengbo,Tang, Guo,Zhao, Yufen
, p. 51776 - 51779 (2014/12/10)
A new and general method for the synthesis of β-hydroxy phosphonates has been achieved through Mn(OAc)3-mediated radical oxidative phosphonation of alkenes with H-phosphonates and H-phosphine oxide. The starting materials of P(O)-H compounds and alkenes are stable and cheap. Mn(OAc)3 can be readily prepared from Mn(OAc)2 in the laboratory. This method can be easily adapted to large-scale preparations. This journal is
Nonenzymatic kinetic resolution of racemic β-hydroxyalkanephosphonates with a chiral copper catalyst
Moriyama, Atsushi,Matsumura, Shintaro,Kuriyama, Masami,Onomura, Osamu
experimental part, p. 810 - 824 (2010/11/04)
Kinetic resolution of β-hydroxyalkanephosphonates was efficiently performed by 2-fluorobenzoylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst with good s value of up to 21.
Enzymes in Organic Chemistry, 11:[1] Hydrolase-Catalyzed Resolution of α- and β-Hydroxyphosphonates and Synthesis of Chiral, Non-Racemic β-Aminophosphonic Acids
Woschek,Lindner, Wolfgang,Hammerschmidt
, p. 1287 - 1298 (2007/10/03)
The enantioselective acylation of racemic diisopropyl α- and β-hydroxyphosphonates by hydrolases in t-butyl methyl ether with isopropenyl acetate as acyl donor is limited by the narrow substrate specificity of the enzymes. High enantiomeric excesses (up t
