192755-43-4

Basic information

• Product Name: Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-
• CAS NO: 192755-43-4
• Molecular Formula: C25H32N4O7
• Molecular Weight: 500.552
• Mol File: 192755-43-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-(192755-43-4)
• EPA Substance Registry System: Butanoic acid, 3-[[[(1S,9S)-9-(benzoylamino)octahydro-6,10-dioxo-6H-pyridazino[1,2- a][1,2]diazepin-1-yl]carbonyl]amino]-4-oxo-, 1,1-dimethylethyl ester, (3S)-(192755-43-4)

Safety Data

• Hazardous Substances Data: 192755-43-4(Hazardous Substances Data)

Upstream product

• 88784-33-2 (2S)-4-benzyloxicarbonyl-2-phthalimidobutanoic acid 
• 192753-53-0 9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester 
• 192753-57-4 (1S,9S)-9-Benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 
• 65632-62-4 (3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester 
• 109364-30-9 (S)-3-amino-N-methoxy-N-methyl-succinamic acid tert-butyl ester 
• 98482-69-0 tert-butyl-(3S)-3-{[(benzyloxy)carbonyl]amino}-4-[methoxy(methyl)amino]-4-oxobutanoate 
• 156699-38-6 (4S)-3-<(3S)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone 
• 156699-39-7 (3S)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid 
• 156699-37-5 (S)-4-benzyl-3-(5-bromopentanoyl)oxazolidine-2-one 
• 41446-22-4 (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester 
• 106928-72-7 (1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 72064-51-8 (3S)-N¹-benzyloxycarbonyl-piperazic acid tert-butyl ester 
• 106860-13-3 (S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 88767-18-4 (S,S)-5-(6-(tert-butoxycarbonyl)tetrahydropyridazin-1(2H)-yl)-4-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid 

Relevant articles and documents

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9- (benzoylamino)octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1- yl]-carbonyl]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

The title compound 1 is a potent interleukin-1β-converting enzyme (ICE) inhibitor. Recently, an efficient chiral synthesis of compound 1 has been accomplished in our labs. The overall yield of this 18-step stereoselective synthesis was 9.8%.