720681-04-9Relevant academic research and scientific papers
Unsurpassed cage effect for the photolysis of dibenzyl ketones in water-soluble dendrimers
Yuan, Zhao,Chen, Jinping,Zeng, Yi,Li, Ying-Ying,Han, Yongbin,Li, Yi
experimental part, p. 6256 - 6264 (2011/10/09)
Amphiphilic water-soluble poly(alkyl aryl ether) dendrimers Gn (n = 1-3) with charge-neutral tetraethylene glycol monomethyl ethers at their periphery were synthesized as microreactors to control the photochemical reactions of dibenzyl ketone derivatives in aqueous solutions. Photophysical studies demonstrated that Gn can encapsulate organic molecules and provide a hydrophobic microenvironment. The product distribution of photolysis of dibenzyl ketone derivatives can be successfully controlled by encapsulating the substrates within dendrimers, and an unsurpassed cage effect of 1.00 is reached in high generation dendrimers, revealing that a thick and compact "shell" was formed at the periphery of the dendrimers. The cage effect is also significantly influenced by the substituent at the para-position of the guest molecules. The higher generation dendrimers exhibit a better confined microenvironment and the aggregates possess more compact cavities to "lock" the guests than the corresponding unimolecular dendrimers. After photolysis, the separation of products can be easily achieved by extracting from the dendrimer solutions and the dendrimers are simply recovered and reused.
Oligosaccharide synthesis by affinity separation based on molecular recognition between podand ether and ammonium ion
Fukase, Koichi,Takashina, Mamoru,Hori, Yumiko,Tanaka, Daizo,Tanaka, Katsunori,Kusumoto, Shoichi
, p. 2342 - 2346 (2007/10/03)
We previously reported a new synthetic methodology termed 'synthesis based on affinity separation' (SAS) in which the desired tagged compound was separated from the reaction mixture by solid-phase extraction using specific molecular recognition of the tag. The interaction between a crown ether tag and polymer-supported ammonium ion was initially employed for SAS. In the present study, a new SAS method using a podand-type tag, a pseudo-benzo-31-crown-10 structure, was elaborated for oligosaccharide synthesis. The podand tag was much easier to synthesize than the corresponding crown ether. The podand moiety was attached to the monosaccharide residue via appropriate linkers. After glycosylation of the tagged monosaccharide with a glycosyl donor, the reaction mixture was subjected to the affinity separation. The desired compounds possessing the podand tag were effectively separated by the affinity between the podand and the ammonium ion. Continuous flow synthesis by integration of a microreactor and the present SAS system was applied for high throughput oligosaccharide synthesis. Georg Thieme Verlag Stuttgart.
Convergent synthesis of AB2-AB3 hybrid-type of amphiphilic oligoethyleneoxy-modified poly(benzyl ether) dendrons
Tang, Dai-Hua,Fan, Qing-Hua
, p. 698 - 699 (2007/10/03)
A new class of AB2-AB3 hybrid-type of amphiphilic oligoethyleneoxy-modified poly(benzyl ether) dendrons has been synthesised by a convergent route.
