72078-82-1

Basic information

• Product Name: N-METHYL-2-NITROACETAMIDE
• Synonyms: RANITIDINE IMPURITY H;N-METHYL-2-NITROACETAMIDE;N-MethylnitroacetaMide-d3;N-MethylnitroacetaMide;N-(Methyl-d3)-2-nitroacetaMide;AcetaMide, N-Methyl-2-nitro-;Ranitidine EP Impurity H;Ranitidine Impurity H (EP)
• CAS NO: 72078-82-1
• Molecular Formula: C₃H₆N₂O₃
• Molecular Weight: 118.09
• Product Categories: Aliphatics;Impurities;Isotope Labelled Compounds
• Mol File: 72078-82-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 68-69 °C
• Boiling Point: 325.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.304 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 6.75±0.58(Predicted)
• CAS DataBase Reference: N-METHYL-2-NITROACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL-2-NITROACETAMIDE(72078-82-1)
• EPA Substance Registry System: N-METHYL-2-NITROACETAMIDE(72078-82-1)

Safety Data

• Hazardous Substances Data: 72078-82-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 72078-82-1 differently. You can refer to the following data:
1. N-Methylnitroacetamide is a degradation product of Ranitidine (R120000).
2. N-Methylnitroacetamide-d3 is a labelled degradation product of Ranitidine (R120000).
3. N-Methylnitroacetamide (Ranitidine EP Impurity H) is a degradation product of Ranitidine (R120000).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Upstream product

• 108-94-1 cyclohexanone 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 
• 66357-35-5 ranitidine hydrochloride 
• 120-92-3 cyclopentanone 
• 98-86-2 acetophenone 
• 97055-51-1 4-Methoxy-1-methyl-3,5-dinitro-2-pyridone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 97055-50-0 1,6-Dimethyl-3,5-dinitro-2-pyridone 
• 97055-58-8 1,4-Dimethyl-3,5-dinitro-2-pyridone 
• 41613-26-7 1,3-dimethyl-5-nitrouracil 
• 108-13-4 malonodiamide 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 

Downstream Products

• 1446238-47-6 4,5-dihydro-N-methyl-5-(phenylsulfonyl)isoxazole-3-carboxamide 
• 144537-05-3 5-phenylisoxazole-3-(N-methyl)carboxamide 
• 41168-87-0 N²-methyl-thiooxalamide 
• 16890-71-4 N-methyldithio-oxamide 
• 13621-47-1 N-methylcyanothioformamide 

Relevant articles and documents

Ring Transformation of 1,4 (or 1,6)-Disubstituted 3,5-Dinitro-2-pyridones with Sodio β-Keto Esters

The ring transformation of 1,6-dimethyl-, 1,4-dimethyl- and 4-methoxy-1-methyl-3,5-dinitro-2-pyridones with sodio β-keto esters to nitrosalicylic esters was investigated concerning the electronic effects of 4 and 6-substitutents.The results were explained by the HSAB principle.

Nucleophilic reaction upon electron-deficient pyridone derivtives. X. One-pot synthesis of 3-nitropyridines by ring transformation of 1-methyl-3,5-dinitro-2-pyridone with ketones or aldehydes in the presence of ammonia

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Pyrimidine Derivatives and Related Compounds. Part 48. Uracil Ring Transformation: Conversion of 5-Nitrouracils into 5-Carbamoyluracils

1,3-Disubstituted 5-nitrouracils (1) react with malonamide in ethanolic sodium ethoxide to afford 1-substituted 5-carbamoyluracils (3) via rearrangement of the N(3)-C(4)-C(5) portion of the uracil.This ring transformation has been applied to the preparation of 2',3',5'-tri-O-acetyl-5-carbamoyluridine (8).