72134-97-5Relevant academic research and scientific papers
TRNA SYNTHETASE INHIBITORS
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Paragraph 00113-00114, (2019/07/30)
Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.
Borenium ion catalyzed hydroboration of alkenes with N-heterocyclic carbene-boranes
Prokofjevs, Aleksandrs,Boussonniere, Anne,Li, Linfeng,Bonin, Helene,Lacote, Emmanuel,Curran, Dennis P.,Vedejs, Edwin
supporting information; experimental part, p. 12281 - 12288 (2012/09/22)
Treatment of alkenes such as 3-hexene, 3-octene, and 1-cyclohexyl-1-butene with the N-heterocyclic carbene (NHC)-derived borane 2 and catalytic HNTf 2 (Tf = trifluoromethanesulfonyl (CF3SO2)) effects hydroboration at room temperature. With 3-hexene, surprisingly facile migration of the boron atom from C(3) of the hexyl group to C(2) was observed over a time scale of minutes to hours. Oxidative workup gave a mixture of alcohols containing 2-hexanol as the major product. A similar preference for the C(2) alcohol was observed after oxidative workup of the 3-octene and 1-cyclohexyl-1-butene hydroborations. NHC-borenium cations (or functional equivalents) are postulated as the species that accomplish the hydroborations, and the C(2) selective migrations are attributed to the four-center interconversion of borenium cations with cationic NHC-borane-olefin π-complexes.
Grignard reagent/borohydride combinations alkylation/reduction of esters
Hallouis, Sophie,Saluzzo, Christine,Amouroux, Roger
, p. 313 - 324 (2007/10/03)
The one step transformation of esters into secondary alcohols (70-80% yields) has been performed with a Grignard reagent in the presence of calcium or zinc borohydride. Under the same conditions, vinylic Grignard reagents gave γ,δ-unsaturated alcohols in good yields through three successive reactions: addition to the ester carbonyl, then conjugate addition and, finally reduction).
A Homoannularly Bridged Hydroxyamino Ferrocene as an Efficient Catalyst for the Enantioselective Ethylation of Aromatic and Aliphatic Aldehydes.
Wally, Hans,Widhalm, Michael,Weissensteiner, Walter,Schoegl, Karl
, p. 285 - 288 (2007/10/02)
Eleven aromatic and aliphatic aldehydes have been alkylated with Et2Zn in the presence of the homoannularly bridged hydroxyamino ferrocene I.The resulting carbinols have e.e's varying from 66 to 97percent.A mechanistic approach is presented to rationalize the preferred formation of the enentiomer observed.
