721401-61-2

Upstream product

• 100-39-0 benzyl bromide 
• 709656-07-5 2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester 
• 65-85-0 benzoic acid 
• 99184-99-3 2-phenyloxazoline-4-carboxylic acid 
• 116956-53-7 sodium 2-phenyloxazoline-4-carboxylate 
• 100-47-0 benzonitrile 
• 55044-06-9 methyl 2-phenyl-2-oxazoline-4-carboxylate 
• 5333-86-8 ethyl benzimidate hydrochloride 

Downstream Products

• 185396-36-5 (S)-α-(hydroxymethyl)-D-phenylalanine 

Relevant academic research and scientific papers

Catalytic Alkylation of 2-Aryl-2-oxazoline-4-carboxylic Acid Esters Using Cyclopeptoids; Newly Designed Phase-Transfer Catalysts

Nonionic, chiral macrocyclic peptoids are efficient phase-transfer catalysts in the C-4 enantioselective alkylation of 2-[4-(trifluoromethyl)phenyl]-2-oxazoline-4-carboxylic acid esters. Screening of the structural features of cyclic peptoids, namely the

Synthesis of protected α-alkyl lanthionine derivatives

Protected α-alkyl lanthionine derivatives were synthesized in five steps starting from a known phenyloxazoline precursor. This approach involved the synthesis of a family of substituted cyclic sulfamidates and their regioselective opening by nucleophilic attack with a protected cysteine. This efficient multistep strategy affords various α-alkylated lanthionine derivatives in high yields.

Practical asymmetric synthesis of α-methylserine derivatives under mild phase-transfer conditions

The enantioselective methylation reaction of phenyloxazoline tert-butyl ester 5 using (R)-4b as a catalyst under mild phase-transfer conditions provides optically active α-methylserine derivatives in moderate yields with high enantioselectivity. Other α-alkylated serine derivatives are also achievable in high yields with high enantioselectivity by using catalytic amount of (R)-4b.

Highly enantioselective synthesis of (R)-α-alkylserines via phase-transfer catalytic alkylation of o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester using cinchona-derived catalysts

(Chemical Equation Presented) A highly enantioselective synthetic method for (R)-α-alkylserines was developed by the phase-transfer catalytic alkylation of obiphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester (4i) using cinchona-derived phase-transfer

Highly enantioselectlve phase-transfer-catalytic alkylation of 2-phenyl-2-oxazoline-4-carboxylic acid tert-butyl ester for the asymmetric synthesis of α-alkyl serines

A facile synthesis of chiral α-alkyl serines 3 involves the asymmetric alkylation of substrates 1 with alkyl halides (RX) under phase-transfer catalysis (PTC), followed by acidic hydrolysis of the alkylation products 2. The phenyl oxazoline moiety enhance