312752-86-6

Usage

Uses

Used in Pharmaceutical Industry:
YM 758 Phosphate is used as a novel cardiovascular agent for the treatment of stable angina and atrial fibrillation, providing a new therapeutic option for patients suffering from these conditions.

Upstream product

• 721452-52-4 ethyl (R)-1-{2-[(4-fluorobenzoyl)amino]ethyl}piperidine-3-carboxylate 
• 403-43-0 4-fluorobenzoyl chloride 
• 95383-37-2 2-bromo-1-(4-fluorobenzamido)ethane 
• 721452-45-5 2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethylamine 
• 721452-55-7 YM-234903 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 312752-85-5 [14C]-YM₇₅₈ 

Relevant academic research and scientific papers

Development of a practical and scalable synthetic route to YM758 monophosphate, a novel If channel inhibitor

A novel, practical, and efficient synthesis of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate (YM758 monophosphate, (R)-1·H3PO4 (Figure 1) is described. The

Novel denzamide derivatives and process for production thereof

There are provided a novel process for the production of an isoquinoline derivative having an inhibitory action for If current; a novel benzamide derivative or a salt thereof used for the production process; and a process for the production of the benzamide derivative or a salt thereof.

NOVEL CRYSTAL OF FLUOROBENZAMIDE DERIVATIVE

There are provided novel crystals of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate.

NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF

The compound of the present invention relates to a drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardiac rate lowering agent, containing the compound as the active ingredient. Namely, the compound has a current If inhibitory effect and is particularly useful as a cardiac rate lowering agent for preventing ischemic heart diseases such as angina and cardiac infarction and circulatory diseases such as congestive cardiac insufficiency and arrhythmia (supraventricular arrhythmia). The present invention relates to dialkoxy-1,2,3,4-tetrahydroquinoline-2-carbonylpiperidino-3,4-dialkoxypropaneanilide derivatives, etc.