72179-84-1

Usage

Uses

Used in Pharmaceutical Industry:
N-methylsulfamide is used as a pharmaceutical compound for the treatment of cancer. As a derivative of Sulfamide, a carbonic anhydrase inhibitor, it plays a significant role in modulating the activity of carbonic anhydrase enzymes, which are often associated with cancer cell growth and proliferation. By targeting these enzymes, N-methylsulfamide can potentially contribute to the inhibition of tumor growth and the overall management of cancer.
Additionally, N-methylsulfamide can be used as a building block or intermediate in the synthesis of other pharmaceutical compounds, further expanding its utility in the development of novel therapeutic agents for various medical conditions.

Upstream product

• 4047-86-3 methyl-μ-imido-disulfuric acid diamide 
• 74-89-5 methylamine 
• 125987-94-2 N-(tert-butoxycarbonyl)-N'-(methyl)sulfamide 
• 10438-96-7 N-methylsulfamoyl chloride 

Downstream Products

• 1025765-26-7 C₂₀H₁₉FN₄O₃S 
• 1033906-16-9 (+/-)-8-cyclohexyl-5-[[[(methylamino)sulfonyl]amino]carbonyl]-1,2b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid methyl ester 
• 1211973-93-1 N-(n-methylsulfamoyl)benzamide 
• 1211973-94-2 4-cyano-N-(n-methylsulfamoyl)benzamide 
• 1438244-01-9 N-methyl-N'-[4-chlorophenylmethylidene]sulfamide 
• 1438244-02-0 N-methyl-N'-[phenylmethylidene]sulfamide 

Relevant academic research and scientific papers

N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis

The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.

Uracil substituted phenyl sulfamoyl carboxamides

Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur; X1=H, halogen, C1-C4-alkyl; X2=H, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl; X3=H, CN, C1-C6-alkyl, C1-C6-alkoxyalkyl, C3-C7-cycloalkyl, C3-C6-alkenyl, C3-C6-alkynyl, optionally substituted benzyl; R1, R2=H, halogen, optionally substituted hydroxy, C1-C10-alkyl, C2-C10-alkenyl, C3-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl or C5-C7-cycloalkenyl, or R1+R2 together with the atom to which they are attached form a 3- to 7-membered heterocyclic ring; Q is selected from Q1 to Q40 as defined in the description. Use: As herbicides; for the desiccation/defoliation of plants.