72179-84-1

Basic information

• Product Name: N-methylsulfamide
• Synonyms: N-methylsulfamide;(MethylsulfaMoyl)aMine;Sulfamide, methyl-
• CAS NO: 72179-84-1
• Molecular Formula: CH₆N₂O₂S
• Molecular Weight: 110.13554
• Mol File: 72179-84-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 65-66℃
• Boiling Point: 206-252℃
• Appearance: /
• Density: 1.401±0.06 g/cm3(Predicted)
• PKA: 11.67±0.60(Predicted)
• Water Solubility: 溶于水
• CAS DataBase Reference: N-methylsulfamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methylsulfamide(72179-84-1)
• EPA Substance Registry System: N-methylsulfamide(72179-84-1)

Safety Data

• Hazardous Substances Data: 72179-84-1(Hazardous Substances Data)

Usage

Uses

N-Methylsulfamide is a useful synthetic compound. N-Methylsulfamide is a derivative of Sulfamide (S699079) which is a carbonic anhydrase inhibitor, used for treatment of cancer.

Upstream product

• 4047-86-3 methyl-μ-imido-disulfuric acid diamide 
• 125987-94-2 N-(tert-butoxycarbonyl)-N'-(methyl)sulfamide 
• 10438-96-7 N-methylsulfamoyl chloride 
• 74-89-5 methylamine 

Downstream Products

• 1438244-01-9 N-methyl-N'-[4-chlorophenylmethylidene]sulfamide 
• 1438244-02-0 N-methyl-N'-[phenylmethylidene]sulfamide 
• 1211973-93-1 N-(n-methylsulfamoyl)benzamide 
• 1211973-94-2 4-cyano-N-(n-methylsulfamoyl)benzamide 
• 1033906-16-9 (+/-)-8-cyclohexyl-5-[[[(methylamino)sulfonyl]amino]carbonyl]-1,2b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid methyl ester 
• 1025765-26-7 C₂₀H₁₉FN₄O₃S 

Relevant articles and documents

N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis

The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.