7218-52-2Relevant articles and documents
Preparation method 4 - hydroxyl -2 - butynoic acid
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Paragraph 0027-0035, (2021/11/19)
The 4 -hydroxyl -2 - butynoic acid preparation method comprises 1, 4 - butynediol as a raw material in an organic solvent and N-O free radical catalyst. The ferrous salt or ferrous salt hydrate or iron salt or iron salt hydrate is oxidized by air or oxygen to obtain 4 - hydroxyl -2 - butyneic acid under the synergistic catalysis of air or oxygen. To the method, the alkyl lithium method commonly adopted in the present production is avoided, the process safety is greatly improved, the production cost is reduced, and the selectivity is close 100% under the optimized process conditions.
Microbial Transformation of 2-Butyn-1,4-diol into 4-Hydroxy-2-butynoic Acid by Specific Oxidation of the Hydroxymethyl Group
Matsumura, Shuichi,Yoda, Nobuo,Endo, Masato,Yoshikawa, Sadao
, p. 647 - 648 (2007/10/02)
2-Butyn-1,4-diol was oxidized quantitatively by the liophilized cell of Rhinocladiella atrovirens KY801 to afford the monocarboxylated product, 4-hydroxy-2-butynoic acid.Neither aldehydes nor degrading compounds were detected in the reaction mixture.