27149-26-4

Usage

Uses

Used in Flavor and Fragrance Industry:
2-(4-ethylphenyl)thiazole is used as a flavoring agent for its strong and distinctive odor, contributing to the unique scents of various products in the fragrance industry.
Used in Natural Products:
2-(4-ethylphenyl)thiazole is found in natural sources such as plants and animals, where it plays a role in their characteristic smell, enhancing the natural aroma of these organisms.
Used in Antimicrobial Applications:
2-(4-ethylphenyl)thiazole is used as an antimicrobial agent due to its potential to inhibit the growth of certain microorganisms, making it a valuable compound in the development of antimicrobial products.
Used in Antifungal Applications:
2-(4-ethylphenyl)thiazole is utilized as an antifungal agent, helping to prevent the growth of fungi, which can be beneficial in various industries, including agriculture and pharmaceuticals.
Used in Antioxidant Applications:
2-(4-ethylphenyl)thiazole is used as an antioxidant, protecting against oxidative stress and damage, which can be applied in the development of health supplements and skincare products to promote overall well-being and skin health.

InChI:InChI=1/C9H6ClNS/c10-8-3-1-7(2-4-8)9-11-5-6-12-9/h1-6H

Upstream product

• 2521-24-6 4-chlorothiobenzamide 
• 17157-48-1 bromoacetaldehyde 
• 106-39-8 bromochlorobenzene 
• 86108-58-9 2-(trimethylstannyl)thiazole 
• 107-20-0 2-chloroethanal 
• 288-47-1 1,3-thiazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 721920-84-9 2-(4-chloro-phenyl)-thiazole-5-carbaldehyde 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1094621-93-8 [2-(4-chloro-phenyl)thiazol-5-yl]methanol 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 623-03-0 4-Cyanochlorobenzene 
• 13084-29-2 2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole 

Downstream Products

• 1186493-11-7 5-benzyl-2-(4-chlorophenyl)thiazole 
• 2227-72-7 2-(4′-chlorophenyl)-4-phenylthiazole 
• 1429329-85-0 1-(2-(4-chlorophenyl)thiazol-5-yl)-1-(pyridin-4-yl)ethanol 

Relevant academic research and scientific papers

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

(Phosphinito)aryl benzimidazole PCN pincer palladium(II) complexes: Synthesis, characterization and catalytic activity in C–H arylation of azoles with aryl iodides

The PCN pincer Pd(II) complexes 4a–c with (phosphinito)aryl benzimidazole ligands were conveniently synthesized by one-pot phosphorylation/palladation reaction of a (2-benzimidazolyl)-containing m-phenol derivative 3. The three complexes were well characterized by spectroscopic methods, elemental analysis and their molecular structures were further determined by X-ray single-crystal diffraction. The Pd(II) center in each complex adopts a typical distorted-square-planar geometry. With a catalyst loading of 0.25–0.5 mol%, complex 4a could effectively catalyze C–H arylation of benzothiazole, benzoxazole and thiazole with various aryl iodides in the presence of CuI as a cocatalyst.

A new face of phenalenyl-based radicals in the transition metal-free C-H arylation of heteroarenes at room temperature: Trapping the radical initiator: Via C-C σ-bond formation

The radical-mediated transition metal-free approach for the direct C-H bond functionalization of arenes is considered as a cost effective alternative to transition metal-based catalysis. An organic ligand-based radical plays a key role by generating an aryl radical which undergoes a subsequent functionalization process. The design principle of the present study takes advantage of a relatively stable odd alternant hydrocarbon-based phenalenyl (PLY) radical. In this study, the first transition metal-free catalyzed direct C-H arylation of a variety of heteroarenes such as azoles, furan, thiophene and pyridine at room temperature has been reported using a phenalenyl-based radical without employing any photoactivation step. This protocol has been successfully applied to the gram scale synthesis of core moieties of bioactive molecules. The phenalenyl-based radical initiator has been characterized crystallographically by trapping it via the formation of a C-C σ-bond between the phenalenyl radical and solvent-based radical species.

Synthesis and Photochromism of Chloro- and tert-Butyl-Functionalized Terarylene Derivatives for Surface Deposition

In the field of extreme miniaturization of electronic devices, it is necessary to study candidate molecules at the single-molecular level by scanning tunneling microscopy (STM). This necessitates molecules with specific functionalizations to control molec

Programmed synthesis of arylthiazoles through sequential C-H couplings

A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

PYRIDINE DERIVATIVES

The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP 17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

Palladium-catalyzed benzylation of heterocyclic aromatic compounds

Broadly applicable palladium-catalyzed heteroarene benzylation reactions are described with a focus on the most challenging heterocyclic classes under traditional benzylation techniques such as sulfur-containing heterocycles and those bearing functional groups that would be incompatible with reactions requiring Lewis acids and/or strong bases.

Photoactivated miticidal and insecticidal ethynyl-thiazoles

Pesticidal 5-ethynyl substituted thizoles, compositions thereof and use thereof as insecticides and miticides are disclosed and exemplified.

Photoactivated miticidal and insecticidal ethynylthiazoles

Pesticidal 2- or 5-ethenyl substituted thiazoles, compositions thereof and use thereof as insecticides and miticides are disclosed and exemplified.