72216-29-6

Upstream product

• 138308-78-8 2-ethyl-6-hydroxybenzaldehyde 
• 77-78-1 dimethyl sulfate 
• 10568-38-4 3-ethylanisole 
• 124-38-9 carbon dioxide 
• 6161-65-5 2-methoxy-6-methyl-benzoic acid 
• 74-88-4 methyl iodide 
• 75-03-6 ethyl iodide 
• 579-75-9 2-Methoxybenzoic acid 
• 620-17-7 3-ethylphenol 
• 256664-93-4 o-Methoxy-benzoesaeure-2'-dimethylhydrazid 
• 256664-94-5 2-ethyl-6-methoxy-benzoic acid N',N'-dimethyl-hydrazide 

Downstream Products

• 909532-85-0 2-ethyl-6-methoxybenzyl alcohol 
• 870288-34-9 C₁₆H₁₆O₃ 
• 909532-86-1 (S)-1-(2-ethyl-6-methoxyphenyl)-3-(triisopropylsilyl)prop-2-yn-1-ol 
• 909532-87-2 (S)-1-(2-ethyl-6-methoxyphenyl)prop-2-yn-1-ol 
• 909532-78-1 (R)-1-(2-ethyl-6-methoxyphenyl)prop-2-yn-1-ol 
• 909532-76-9 (R)-3-ethyl-2-(1-hydroxyallyl)phenol 
• 909532-89-4 (R)-1-(2-ethyl-6-methoxyphenyl)prop-2-en-1-ol 
• 909532-77-0 2-ethyl-6-methoxybenzaldehyde 

Relevant academic research and scientific papers

PENTACYCLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.

Asymmetric total synthesis of (-)-panacene and correction of its relative configuration

The first synthesis of (-)-panacene has been accomplished in concise, highly stereoselective fashion from commercially available 2-methoxy-6- methylbenzoic acid (15 steps, 8.3% overall yield). The synthesis unambiguously establishes the correct relative a

SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.

New reactions of hydrazides. Part 1: Directed ortho- and lateral metalation of aromatic carbocyclic and heterocyclic systems

Aromatic and heterocyclic 2,2-dialkylhydrazides undergo directed metalation with 2 equivalents of n-, s- or t-BuLi, and the resulting C,N- dilithio species react with a variety of electrophiles. The products may be readily converted to the corresponding carboxylic acids or esters by oxidation with manganese dioxide in water or methanol containing acetic acid.