72277-18-0

Basic information

• Product Name: Benzenebutanoic acid, b-phenyl-, ethyl ester
• CAS NO: 72277-18-0
• Molecular Formula: C18H20O2
• Molecular Weight: 268.356
• Mol File: 72277-18-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenebutanoic acid, b-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoic acid, b-phenyl-, ethyl ester(72277-18-0)
• EPA Substance Registry System: Benzenebutanoic acid, b-phenyl-, ethyl ester(72277-18-0)

Safety Data

• Hazardous Substances Data: 72277-18-0(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 36032-75-4 triethyl phosphonoacetate 
• 64-17-5 ethanol 
• 4374-49-6 3-benzyl-3-phenylpropionic acid 
• 1026409-03-9 1-((Z)-1-Ethoxy-3,4-diphenyl-but-1-enyl)-1H-[1,2,4]triazole 
• 14371-10-9 (E)-3-phenylpropenal 
• 100-39-0 benzyl bromide 
• 136290-37-4 1-((E)-1-Ethoxy-3-phenyl-allyl)-1H-[1,2,4]triazole 
• 183678-79-7 3-(benzotriazol-1-yl)-3-ethoxy-1-phenyl-1-propene 
• 72277-01-1 diethyl 1-trimethylsilyloxy-3-phenyl-2-propenylphosphonate 
• 7381-89-7 ethyl ester of (racemic) 2,3-diphenylcyclopropane-1-carboxylic acid 
• 103-30-0 (E)-1,2-diphenyl-ethene 

Downstream Products

• 939381-82-5 Methanesulfonic acid 3,4-diphenyl-butyl ester 
• 143747-70-0 3,4-diphenylbutan-1-ol 

Relevant articles and documents

Rhodium Porphyrin Catalyzed Regioselective Transfer Hydrogenolysis of C-C σ-Bonds in Cyclopropanes with iPrOH

A new rhodium porphyrin catalyzed regioselective transfer hydrogenolysis of both activated and unactivated cyclopropanes employing iPrOH as the hydrogen source was discovered. The reaction mechanism for the C-C σ-bond activation of cyclopropanes was identified through an initial radical substitution with rhodium(II) metalloporphyrin radical to give a rhodium porphyrin alkyl, followed by hydrogenolysis with iPrOH to give the corresponding acyclic alkanes and regenerate rhodium(II) metalloporphyrin radical.

Benzotriazole- and 1,2,4-triazole-stabilized allylic anions: Applications in syntheses of functionalized α,β-unsaturated ketones, γ-lactones, γ-lactams, and β-substituted esters

Deprotonated 1-(benzotriazol-1-yl)-1-ethoxy-2-hexene (7) reacted with alkyl halides, aldehydes, ketones, imines, and α,β-unsaturated esters to give exclusively the α-alkylated products 8a-c, 10a,b, 12, 14, 16, and 18a,b, respectively. Without isolation, these products were hydrolyzed under mild conditions to generate the corresponding simple or functionalized α,β-unsaturated ketenes 9a-c, 11a,b, 13, 15, 17, and 19a,b. Similar reactions with the phenyl-substituted analog 3-(benzotriazol-1-yl)-3-ethoxy-1-phenyl-1-propene (21) also gave the analogous α-products, but they were accompanied by small amounts of the γ-products in most cases. By contrast, deprotonation of the corresponding triazole derivative 29 with butyllithium followed by reactions with alkyl halides, aldehydes, ketones, or imines yielded exclusively γ-alkylated adducts 32, 34, 36, 38, 40, and 42. Intermediates 32, 34, 36, 38, 40, and 42 were readily converted into β-substituted esters 33a-c, γ-lactones 35a,b, 39, 41, and 43, and γ-lactams 37a-c on hydrolysis.

Silyl Phosphites. XVIII. Versatile Utility of α-(Trimethylsilyloxy)-alkylphosphonates as Key Intermediates for Transformation of Aldehydes into Several Carbonyl Derivatives

Carbonyl addition compounds of diethyl trimethylsilyl phosphite (DTMSP) with aldehydes were converted, by treatment with lithium diisopropylamide (LDA) followed by the successive alkylation and alkaline hydrolysis, to carbonyl derivatives involving aldehydes, unsymmetrical ketones, β,γ-unsaturated ketones, and carboxylic acids. β-Substituted carboxylic esters and γ-substituted lactones were prepared by use of the carbonyl addition compounds of DTMSP with α,β-unsaturated aldehydes.