72324-44-8

Basic information

• Product Name: N-p-Tolyl-MalonaMic acid ethyl ester
• Synonyms: N-p-Tolyl-MalonaMic acid ethyl ester
• CAS NO: 72324-44-8
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 72324-44-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 390.5°C at 760 mmHg
• Flash Point: 190°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 2.64E-06mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: N-p-Tolyl-MalonaMic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-p-Tolyl-MalonaMic acid ethyl ester(72324-44-8)
• EPA Substance Registry System: N-p-Tolyl-MalonaMic acid ethyl ester(72324-44-8)

Safety Data

• Hazardous Substances Data: 72324-44-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15NO3/c1-3-16-12(15)8-11(14)13-10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3,(H,13,14)

Upstream product

• 106-49-0 p-toluidine 
• 105-53-3 diethyl malonate 
• 6876-54-6 2-cyano-N-(4-methylphenyl)acetamide 
• 64-17-5 ethanol 
• 270577-95-2 (2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-p-tolylamino-acetonitrile 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 95262-01-4 N-p-tolyl-malonamic acid 

Downstream Products

• 142917-15-5 N-methyl-N'-p-tolyl-malonamide 
• 13663-98-4 2-Aethoxycarbonyl-monothiomalonsaeure-bis-<4-methyl-anilid> 
• 14710-90-8 3-p-Tolylcarbamoyl-2-chinolon 
• 147509-33-9 p-toluidide of 3-(2-nitrophenyl)-2-carbethoxyacrylic acid 
• 861346-70-5 bromo-malonic acid benzylamide-p-toluidide 
• 1391914-15-0 ethyl 3-oxo-2,2-diphenyl-3-(p-tolylamino)propanoate 
• 79612-93-4 2-[1,3]Dithiolan-2-ylidene-N-p-tolyl-malonamic acid ethyl ester 
• 144041-08-7 2-Chloro-N-(2-hydrazinocarbonyl-acetyl)-N-p-tolyl-benzamide 
• 144041-09-8 4-Chloro-N-(2-hydrazinocarbonyl-acetyl)-N-p-tolyl-benzamide 
• 144041-07-6 2-<(N-Benzoyl)-p-methylanilido>acetohydrazide 

Relevant articles and documents

Synthesis of 3-(alkylamino and anilino)-4-benzyloxycarbonyl-1H-pyrrole-2,5-diones via 5-[(alkylamino and anilino)(cyano)]-2,2-dimethyl-1,3-dioxane-4,6-diones

Treatment of [(alkylamino and anilino)(cyano)methylene]-2,2-dimethyl-1,3-dioxane-4,6-diones with benzyl alcohol for 20 min at reflux gave 3-(alkylamino and anilino)-4-benzyloxycarbonylmaleimides.

Malonic ester amide synthesis: An efficient methodology for synthesis of amides

A general methodology malonic ester amide synthesis has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Copyright

Antimicrobial study of some indole derivatives

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