72324-44-8

Usage

InChI:InChI=1/C12H15NO3/c1-3-16-12(15)8-11(14)13-10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3,(H,13,14)

Upstream product

• 64-17-5 ethanol 
• 95262-01-4 N-p-tolyl-malonamic acid 
• 106-49-0 p-toluidine 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 105-53-3 diethyl malonate 
• 270577-95-2 (2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-p-tolylamino-acetonitrile 
• 6876-54-6 2-cyano-N-(4-methylphenyl)acetamide 

Downstream Products

• 142917-15-5 N-methyl-N'-p-tolyl-malonamide 
• 13663-98-4 2-Aethoxycarbonyl-monothiomalonsaeure-bis-<4-methyl-anilid> 
• 39052-54-5 3-hydrazinyl-3-oxo-N-(p-tolyl)propanamide 
• 144041-04-3 ethyl 2-<(N-benzoyl)-p-methylanilido>ethanoate 
• 144041-06-5 3-[(4-Chloro-benzoyl)-p-tolyl-amino]-3-oxo-propionic acid ethyl ester 
• 14710-90-8 3-p-Tolylcarbamoyl-2-chinolon 
• 147509-33-9 p-toluidide of 3-(2-nitrophenyl)-2-carbethoxyacrylic acid 
• 130832-77-8 7-methyl-2-(p-tolylamino)-2-ethoxycarbonyl-2H-1,4-benzothiazine-3(4H)-one 
• 130832-80-3 2-(2-Carboxy-phenylamino)-7-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-2-carboxylic acid ethyl ester 
• 130832-82-5 7-methyl-2-(2-morpholinoethylamine)-2-ethoxycarbonyl-2H-1,4-benzthiazin-3(4H)-one 
• 130832-81-4 7-methyl-2-<(4-ethoxycarbonylphenyl)methylamino>-2-ethoxycarbonyl-2H-1,4-benzthiazin-3(4H)-one 
• 130832-79-0 2-[4-(Difluoro-methanesulfonyl)-phenylamino]-7-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-2-carboxylic acid ethyl ester 
• 1391914-15-0 ethyl 3-oxo-2,2-diphenyl-3-(p-tolylamino)propanoate 
• 861346-70-5 bromo-malonic acid benzylamide-p-toluidide 

Relevant academic research and scientific papers

Synthesis of 3-(alkylamino and anilino)-4-benzyloxycarbonyl-1H-pyrrole-2,5-diones via 5-[(alkylamino and anilino)(cyano)]-2,2-dimethyl-1,3-dioxane-4,6-diones

Treatment of [(alkylamino and anilino)(cyano)methylene]-2,2-dimethyl-1,3-dioxane-4,6-diones with benzyl alcohol for 20 min at reflux gave 3-(alkylamino and anilino)-4-benzyloxycarbonylmaleimides.

Synthesis and properties of 5-hydroxy-1-tolyl(benzyl)-1,2,3-triazoles

[Figure not available: see fulltext.] 1-Benzyl-N-tolyl-1,2,3-triazole-4-carboxamide was accessed via rearrangement of N-benzyl-1-tolyl-1,2,3-triazole-4-carboxamide. It is shown that by boiling in various solvents an equilibrium between isomeric triazoles

Malonic ester amide synthesis: An efficient methodology for synthesis of amides

A general methodology malonic ester amide synthesis has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Copyright

Ethyl malonate amides: A diketo acid offspring fragment for HIV integrase inhibition

While searching for new HIV integrase inhibitors we discovered that some ethyl malonate amides (EMA) are active against this enzyme. Surprisingly, the main function can only very rarely be found among the reported drug candidates. We synthesised a series