72326-99-9

Basic information

• Product Name: Benzoic acid, 2-formyl-3,4,5-trimethoxy-, methyl ester
• CAS NO: 72326-99-9
• Molecular Formula: C12H14O6
• Molecular Weight: 254.24
• Mol File: 72326-99-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-formyl-3,4,5-trimethoxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-formyl-3,4,5-trimethoxy-, methyl ester(72326-99-9)
• EPA Substance Registry System: Benzoic acid, 2-formyl-3,4,5-trimethoxy-, methyl ester(72326-99-9)

Safety Data

• Hazardous Substances Data: 72326-99-9(Hazardous Substances Data)

Upstream product

• 118-41-2 Eudesmic acid 
• 1535-67-7 difluoromethyl phenyl sulfide 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 4885-02-3 Dichloromethyl methyl ether 
• 23346-82-9 2-bromo-3,4,5-trimethoxybenzoic acid 
• 56440-94-9 2-formyl-3,4,5-trimethoxybenzoic acid 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl) methane

Difluoro(phenylsulfanyl)methane (PhSCF 2 H) was found to undergo a reaction with aromatic compounds mediated by SnCl 4, through a thionium intermediate characterized by NMR and TD-DFT analyses, leading to the formation of a mixture of S, S ′-diphenyl dithioacetal and aromatic aldehyde which, after oxidative hydrolysis, provides the aromatic aldehyde in good to excellent yields. The salient feature of the present work is the reaction of activated aromatic compounds containing a deactivating ester functional group, leading to the formylated products in good yields.

Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade

A Zn-mediated propargylation/lactamization cascade reaction with chiral 2-formylbenzoate derived N-tert-butanesulfinyl imines was realized, which provided a practical and efficient method for the synthesis of chiral isoindolinones. High diastereoselectivities (up to 97:3 dr) and good reaction yields were observed for most examined cases.

Benzofuran derivatives and their use as antibacterial agents

The invention relates to novel benzofuran derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as anti-infectives.