72458-46-9

Upstream product

• 19130-96-2 1,5-dideoxy-1,5-imino-D-glucitol 
• 100-39-0 benzyl bromide 
• 214342-03-7 (1R,2R)-2-Benzylamino-1-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-3-en-1-ol 
• 214342-00-4 (3aS,6R,7R,7aS)-5-Benzyl-2,2-dimethyl-6-vinyl-hexahydro-[1,3]dioxolo[4,5-c]pyridin-7-ol 
• 132352-47-7 (E)-3-((4S,5S)-5-((4-ethoxybenzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-ol 
• 132352-49-9 ethyl (E)-3-((4S,5S)-5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 132198-14-2 N-Benzhydryl-1-deoxynojirimycin 
• 214342-01-5 (3aS,6R,7R,7aS)-5-Benzyl-6-hydroxymethyl-2,2-dimethyl-hexahydro-[1,3]dioxolo[4,5-c]pyridin-7-ol 
• 531515-01-2 (E)-ethyl (4S,5S)-4,5-dihydroxy-6-(4-methoxybenzyloxy)-hex-2-enoate 
• 129083-15-4 {(2S,3R)-3-[(4R,5S)-5-(4-Methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-oxiranyl}-methanol 

Downstream Products

• 149302-60-3 N-benzyl-2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin 
• 114040-90-3 N-benzyl-3-O-benzyl-1,5-dideoxy-1,5-imino-4,6-O-isopropylidene-2-O-(trifluoro-methyl)sulfonyl-D-mannitol 
• 114040-87-8 N-benzyl-1,5-dideoxy-1,5-imino-4,6-O-isopropylidene-2,3-di-O-(methylsulfonyl)-D-glucitol 
• 114040-91-4 2-azido-N-benzyl-3-O-benzyl-1,2,5-trideoxy-1,5-imino-4,6-O-isopropylidene-D-glucitol 
• 114040-93-6 2-acetamido-N-benzyl-3-O-benzyl-1,2,5-trideoxy-1,5-imino-4,6-O-isopropylidene-D-glucitol 
• 114040-92-5 (4aR,7S,8R,8aR)-5-Benzyl-8-benzyloxy-2,2-dimethyl-hexahydro-[1,3]dioxino[5,4-b]pyridin-7-ylamine 
• 114040-89-0 N-benzyl-3-O-benzyl-1,5-dideoxy-1,5-imino-4,6-O-isopropylidene-D-mannitol 
• 114040-88-9 N-benzyl-1,2,3,5-tetradeoxy-1,5-imino-4,6-O-isopropylidene-D-erythro-2-hexenitol 
• 105265-96-1 2-acetamido-1,2-dideoxynojirimycin 
• 114129-23-6 N-benzyl-1,5-dideoxy-1,5-imino-4,6-O-isopropylidene-D-mannitol 
• 149302-61-4 N-<(p-fluorophenoxy)ethyl>-2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin 
• 69567-11-9 2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol 
• 19130-96-2 1,5-dideoxy-1,5-imino-D-glucitol 
• 114040-86-7 N-benzyl-1,5-dideoxy-1,5-imino-4,6-O-isopropylidene-D-glucitol 

Relevant academic research and scientific papers

Gas-phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl deoxynojirimycin

The deoxynojirimycin (DNJ) family of imino sugars are glucose analogues with an NH group replacing the oxygen atom in the pyranose ring. They are powerful inhibitors of glycosidases and ceramide glucosyltransferases. The conformation of N-benzyl-DNJ, isol

Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

USE OF N-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS IN COMBINATION THERAPY FOR TREATING HEPATITIS VIRUS INFECTIONS

Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

Use of alkylated iminosugars to treat multidrug resistance

Methods and compositions for preventing, reducing, or reversing multidrug resistance (MDR) during cancer chemotherapy in patients undergoing treatment with therapeutically effective amounts of chemotherapeutic agents are provided. The methods comprise administering an anti-MDR effective amount of an N-substituted-1,5-dideoxy-1,5-imino-D-glucitol or galactitol iminosugar to a patient.

Isotope edited NMR studies of glycosidases: Design and synthesis of a novel glycosidase inhibitor

N-13C-methyl-deoxynojirimycin was synthesized and used in isotope- edited NMR studies to probe the binding site of an α-glucosidase. Results from this analysis led to the design and preparation of a novel α- glucosidase inhibitor, N-glycyl deoxynojirimycin.

Asymmetric synthesis of (+)-1-deoxynojirimycin

An asymmetric synthesis of (+)-1-deoxynojirimycin (1) in 14 steps starting from diene (5) is described. The key transformations in the sequence are a sharpless dihydroxylation and epoxidation followed by a regio- and stereoselective aminolysis of vinyl epoxide 11 to give piperidine 12.

The chemistry of the 1-deoxynojirimycin system. Synthesis of 2-acetamido-1,2-dideoxynojirimycin from 1-deoxynojirimycin.

The synthesis of 2-acetamido-1,2-dideoxynojirimycin (2-acetamido-1,2,5-tri-deoxy-1,5-imino-D-glucitol) by a double inversion procedure starting from 1-deoxynojirimycin is reported. The key intermediates were the selectively protected N-benzyl-1,5-dideoxy-