724702-31-2Relevant academic research and scientific papers
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)
Monaldi, Daria,Rotili, Dante,Lancelot, Julien,Marek, Martin,W?ssner, Nathalie,Lucidi, Alessia,Tomaselli, Daniela,Ramos-Morales, Elizabeth,Romier, Christophe,Pierce, Raymond J.,Mai, Antonello,Jung, Manfred
, p. 8733 - 8759 (2019/10/11)
The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary and urgent. To this end, the targeting of Schistosoma m
Facile synthesis of pyrazolo[3,4-d]pyrimidines and pyrimido[4,5-d] pyrimidin-4-one derivatives
Katiyar, Sanjay Babu,Kumar, Arun,Chauhan, Prem M. S.
, p. 2963 - 2973 (2007/10/03)
Pyrazolopyrimidine and pyrimidopyrimidine derivatives have shown a wide range of biological activities such as acting as A1 adenosine receptors, kinase insert domain receptor (KDR), Rous sarcoma oncogene (Src), epidermal growth factor receptor (EGFR), antiproliferative, dihydrofolate reductase (DHFR), antimicrobial, antifungal, and lipid peroxidation. Because of this wide range of activities, we have synthesized pyrazolo[3,4-d]pyrimidines and pyrimido[4,5-d]pyrimidin-4-one derivatives. Copyright Taylor & Francis Group, LLC.
