7249-26-5

Basic information

• Product Name: 7-hydroxy-5-methyl-2H-chromen-2-one
• CAS NO: 7249-26-5
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.1687
• Mol File: 7249-26-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 393.9°C at 760 mmHg
• Flash Point: 183.1°C
• Density: 1.336g/cm³
• Vapor Pressure: 9.1E-07mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 7-hydroxy-5-methyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-5-methyl-2H-chromen-2-one(7249-26-5)
• EPA Substance Registry System: 7-hydroxy-5-methyl-2H-chromen-2-one(7249-26-5)

Safety Data

• Hazardous Substances Data: 7249-26-5(Hazardous Substances Data)

Upstream product

• 504-15-4 orcinol 
• 617-48-1 malic acid 
• 80813-61-2 5-methyl-7-acetoxycoumarin 
• 471-25-0 Propiolic acid 
• 623-47-2 propynoic acid ethyl ester 
• 52400-12-1 7-hydroxy-5-methylcoumarin-3-carboxylic acid ethyl ester 
• 487-69-4 2,4-dihydroxy-6-methylbenzaldehyde 
• 10601-80-6 ethyl 3,3-diethoxypropanoate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 873378-18-8 7-hydroxy-5-methyl-2-oxo-2H-chromene-3-carboxylic acid 

Downstream Products

• 245736-81-6 5-methyl-7-(2'-oxocyclohexyloxy)coumarin 
• 113765-78-9 C₁₇H₁₂O₄ 
• 76605-65-7 5,5'-dimethylangelicin 
• 73459-03-7 5-methylangelicin 
• 54745-57-2 5-(bromomethyl)-7-methoxy-2H-chromen-2-one 
• 139287-00-6 2-[(7-Hydroxy-5-methyl-2-oxo-2H-chromen-8-ylmethyl)-amino]-3-phenyl-propionic acid 

Relevant articles and documents

Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(-)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway

This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(-)-cis-khellactones. The newly synthesized compounds were characterized by1H nuclear magnetic resonance (NMR),13

A catalyst-free one-pot construction of skeletons of 5-methoxyseselin and alloxanthoxyletin in water

In refluxing water and without an additional catalyst, electron-rich phenols could react with alkynoic acids or alkynoates to provide coumarin structures. The skeletons of two natural pyranocoumarins, 5-methoxyseselin and alloxanthoxyletin, could be constructed (total yield up to 76%) in an aqueous multicomponent reaction in which isoprenyl acetate, propiolic acid, and phloroglucinol were simply mixed and refluxed in water.

Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study

Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of 1a were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 μg/mL) than 1a (MIC = 6.25 μg/mL), and is even potent than the positive control metronidazole (MIC = 0.50 μg/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of 1a have also led to an outline of structure-activity relationship.