7249-51-6

Basic information

• Product Name: N-[2-(dimethylamino)ethyl]formamide
• CAS NO: 7249-51-6
• Molecular Formula: C₅H₁₂N₂O
• Molecular Weight: 116.1616
• Mol File: 7249-51-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.3°C at 760 mmHg
• Flash Point: 96.7°C
• Density: 0.933g/cm³
• Vapor Pressure: 0.0477mmHg at 25°C
• Refractive Index: 1.438
• CAS DataBase Reference: N-[2-(dimethylamino)ethyl]formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(dimethylamino)ethyl]formamide(7249-51-6)
• EPA Substance Registry System: N-[2-(dimethylamino)ethyl]formamide(7249-51-6)

Safety Data

• Hazardous Substances Data: 7249-51-6(Hazardous Substances Data)

Usage

General Description

N-[2-(dimethylamino)ethyl]formamide, also known as N,N-dimethyl-2-formamidoethylamine, is a chemical compound that consists of a formamide group attached to a dimethylaminoethyl side chain. It is commonly used as a building block in organic synthesis and pharmaceutical manufacturing. N-[2-(dimethylamino)ethyl]formamide is a versatile reagent that can undergo various chemical reactions, including acylation, alkylation, and amidation. It is also used as a solvent in chemical reactions and as a stabilizer for certain pharmaceutical formulations. Additionally, it can function as a chelating agent for metal ions in solution. Due to its diverse applications, this chemical is used in a wide range of industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 64-18-6 formic acid 
• 108-00-9 N,N-dimethylethylenediamine 
• 75-87-6 chloral 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 142-25-6 N,N',N'-trimethylenediamine 
• 1238784-85-4 4'-[[2-n-Propyl-4-methyl-6-[1-(2-dimethylamino-ethyl)-4,5-dimethyl-imidazol-2-yl]-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic Acid 
• 56635-61-1 N-(2-Dimethylamino-ethyl)-2,N-dimethyl-benzamide 
• 20916-86-3 3-Methyl-benzoesaeure--amid 
• 20916-85-2 N-<2-(Dimethylamino)ethyl>-N-methylbenzamides 

Relevant articles and documents

Amide-ligand-controlled highly para-selective arylation of monosubstituted simple arenes with arylboronic acids

Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and found to be critical for the selectivity control in current arylations.

Long-range anisotropic effects of long chain amides

In 1H-NMR spectra of amids with long-chain aliphatic N-substituents one observes - despite of the free mobility of the aliphatic chain - splitting of the signals of the terminal methyl groups which is caused by the hindered rotation of the amide bond. - Keywords: Amides; Hindered rotation; 1H-NMR