7250-28-4

Basic information

• Product Name: 4-methyl-1-(2-oxo-2-phenylethyl)pyridinium
• Synonyms: 4-Methyl-1-(2-oxo-2-phenylethyl)pyridinium; Pyridinium, 4-methyl-1-(2-oxo-2-phenylethyl)-
• CAS NO: 7250-28-4
• Molecular Formula: Br*C₁₄H₁₄NO
• Molecular Weight: 212.2665
• Mol File: 7250-28-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4-methyl-1-(2-oxo-2-phenylethyl)pyridinium(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-1-(2-oxo-2-phenylethyl)pyridinium(7250-28-4)
• EPA Substance Registry System: 4-methyl-1-(2-oxo-2-phenylethyl)pyridinium(7250-28-4)

Safety Data

• Hazardous Substances Data: 7250-28-4(Hazardous Substances Data)

Upstream product

• 108-89-4 picoline 
• 70-11-1 α-bromoacetophenone 
• 2033-24-1 cycl-isopropylidene malonate 
• 100-52-7 benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 769-42-6 1,3-dimethylbarbituric acid 
• 104-87-0 4-methyl-benzaldehyde 
• 3282-32-4 2-diazo-acetophenone 

Downstream Products

• 108-89-4 picoline 
• 98-86-2 acetophenone 
• 25357-50-0 4-methylpyridinium phenacylide 
• 885-91-6 2-phenyl-7-methylimidazo[1,2-a]pyridine 
• 40624-45-1 ethyl 3-benzoyl-7-methylindolizine-1-carboxylate 
• 73916-32-2 [2-furan-2-yl-7-methyl-1-(5-nitro-furan-2-yl)-indolizin-3-yl]-phenyl-methanone 

Relevant articles and documents

Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

Facile one-pot tandem synthesis of perfluoroalkylated indolizines under metal-free mild conditions

A direct metal-free method for the synthesis of perfluoroalkylated indolizines by means of DIPEA-promoted tandem C[sbnd]N/C[sbnd]C bond formation was developed. Various substituted pyridines and bromoacetyl derivatives with methyl perfluoroalk-2-ynoates proceeded smoothly in this mild transformation, and the desired products were obtained in good to excellent yields under air.

Transition-Metal-Free Synthesis of Indolizines from Electron-Deficient Alkenes via One-Pot Reaction Using TEMPO as an Oxidant

A one-pot method for the synthesis of multisubstituted indolizines from α-halo carbonyl compounds, pyridines, and electron-deficient alkenes is reported. The oxidative dehydrogenation reaction takes place under transition-metal-free conditions using TEMPO as an oxidant. This protocol uses ready available starting materials in a convenient procedure under mild reaction conditions.