7250-71-7

Basic information

• Product Name: 3-phenoxypropylene di(acetate)
• Synonyms: 3-phenoxypropylene di(acetate);3-(Phenoxy)propane-1,2-diol diacetate;3-Phenoxypropane-1,2-diol diacetate;1,2-Propanediol, 3-phenoxy-, diacetate;1-Phenyl ether-2,3-diacetate glycerol;3-Phenoxy-1,2-propanediol diacetate;Ai3-07927;Brn 1981828
• CAS NO: 7250-71-7
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.26314
• EINECS: 230-661-2
• Mol File: 7250-71-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 355.44°C (rough estimate)
• Flash Point: 158.1°C
• Appearance: /
• Density: 1.2380 (rough estimate)
• Vapor Pressure: 2.27E-05mmHg at 25°C
• Refractive Index: 1.4825 (estimate)
• CAS DataBase Reference: 3-phenoxypropylene di(acetate)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenoxypropylene di(acetate)(7250-71-7)
• EPA Substance Registry System: 3-phenoxypropylene di(acetate)(7250-71-7)

Safety Data

• Hazardous Substances Data: 7250-71-7(Hazardous Substances Data)

Usage

General Description

3-phenoxypropylene di(acetate) is a chemical compound that is also known by its IUPAC name, 3-phenoxypropane-1,2-diyl diacetate. It is a clear liquid with a slightly sweet odor. 3-phenoxypropylene di(acetate) is commonly used as a solvent, particularly in the production of synthetic resins and lacquers. It is also used in the manufacturing of plastics, pharmaceuticals, and agricultural products. 3-phenoxypropylene di(acetate) is known for its high solvency and low volatility, making it an effective ingredient in various industrial applications. However, it is important to handle this chemical with caution as it can be harmful if swallowed, inhaled, or absorbed through the skin, and proper safety measures should be taken when working with it.

InChI:InChI=1/C13H16O5/c1-10(14)16-8-13(18-11(2)15)9-17-12-6-4-3-5-7-12/h3-7,13H,8-9H2,1-2H3

Upstream product

• 538-43-2 3-phenoxy-1,2-propanediol 
• 108-24-7 acetic anhydride 
• 108-05-4 vinyl acetate 
• 122-60-1 Phenyl glycidyl ether 
• 1746-13-0 allyl phenyl ether 
• 64-19-7 acetic acid 
• 63715-95-7 1-O-acetyl-3-(phenoxy)propane-1,2-diol 
• 75-05-8 acetonitrile 

Relevant articles and documents

Diol-Ritter Reaction: Regio- And Stereoselective Synthesis of Protected Vicinal Aminoalcohols and Mechanistic Aspects of Diol Monoester Disproportionation

The well-known epoxide-Ritter reaction generally affords oxazolines with poor to average regioselectivity. Herein, a mechanism-based study of the less known diol-Ritter reaction has provided a highly regioselective procedure for the synthesis of 1-vic-amido-2-esters from either terminal epoxides or 1,2-diols via Lewis acid-catalyzed monoesterification. When treated with a stoichiometric Lewis acid catalyst (BF3), these diol monoesters form dioxonium cation intermediates that are ring-opened with nitrile nucleophiles to form nitrilium intermediates, which undergo rapid and irreversible hydration to give the desired amidoesters. Diester byproduct formation is irreversible and appears to occur through disproportionation of diol monoester. With chiral epoxide starting materials, the formation of amidoester occurs with retention of configuration and no apparent erosion of optical purity as determined by single-crystal X-ray analyses and chiral chromatography, respectively. The direct access to chiral vic-amidoesters is especially practical with regard to the synthesis of antibacterial oxazolidinone analogues of the Zyvox antimicrobial family.

Heterogeneous acidic and eco-friendly reagents for mild and convenient conversion of epoxides to 1,2-diacetates

A highly regioselective ring-opening of epoxides with acetic anhydride in the presence of hydrated disodium hydrogen phosphate and sodium hydrogen sulfate as efficient and eco-friendly reagents is described. The reactions are clean and lead to 1,2-diacetates in high to excellent yields.

Aerobic palladium-catalyzed dioxygenation of alkenes enabled by catalytic nitrite

Catalytic nitrite was found to enable carbon-oxygen bond-forming reductive elimination from unstable alkyl palladium intermediates, providing dioxygenated products from alkenes. Avariety of functional groups were tolerated, and high yields (up to 94%) were observed with many substrates, also for a multigram-scale reaction. Nitrogen dioxide, which could form from nitrite under the reaction conditions, was demonstrated to be a potential intermediate in the catalytic cycle. Furthermore, the reductive elimination event was probed with 18O-labeling experiments, which demonstrated that both oxygen atoms in the difunctionalized products were derived from one molecule of acetic acid.