72571-05-2

Upstream product

• 72571-04-1 ethyl [[2-(4-bromophenyl)-2-oxoethyl]amino]oxoacetate 
• 2999-46-4 Ethyl isocyanoacetate 
• 99-90-1 para-bromoacetophenone 
• 5467-72-1 α-amino-4-bromoacetophenone hydrochloride 
• 99-73-0 para-bromophenacyl bromide 
• 586-75-4 4-chlorobenzoyl chloride 
• 33277-15-5 ethyl 5-(4-bromo-phenyl)-isoxazole-3-carboxylate 

Downstream Products

• 72571-06-3 5-(4-bromophenyl)oxazole 

Relevant academic research and scientific papers

Development of a continuous flow photoisomerization reaction converting isoxazoles into diverse oxazole products

A continuous flow process is presented, which directly converts isoxazoles into their oxazole counterparts via a photochemical transposition reaction. This results in the first reported exploitation of this transformation to establish its scope and synthe

Silver-Induced [3+2] Cycloaddition of Isocyanides with Acyl Chlorides: Regioselective Synthesis of 2,5-Disubstituted Oxazoles

A silver-induced cycloaddition of isocyanides with acyl chlorides has been developed. This transition metal-catalyzed strategy provides an effective and scalable approach for the formation of 2,5-disubstituted oxazoles in good to high yields. The employed silver-based MOF catalyst can be efficiently recycled without compromising the yield.

I2-Promoted formal [3+2] cycloaddition of α-methylenyl isocyanides with methyl ketones: a route to 2,5-disubstituted oxazoles

An I2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving the C≡N cleavage of isocyanides. The salient feature of this approach is unconventional 2,5-disubstituted oxazole formation from isocyanides and ketones rather than 4,5-substituted oxazoline.

5-(4-Bromophenyl)oxazole

The compound 5-(4-bromophenyl)oxazole is useful as an antifungal agent.