72583-84-7

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 100-63-0 phenylhydrazine 
• 108-86-1 bromobenzene 
• 6752-16-5 1H-pyrazolo[3,4-b]pyridin-3-amine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 685522-75-2 3-iodo-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 1345014-88-1 2-phenyl-4-[(1-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)amino]-7,8-dihydro-1,6-naphthyridin-5(6H)-one 
• 116834-99-2 1,3-diphenyl-1H-pyrazolo[3,4-b]pyridine 

Relevant academic research and scientific papers

Copper-Catalyzed N1 Coupling of 3-Aminoindazoles and Related Aminoazoles with Aryl Bromides

The N1-selective arylation of 3-aminoindazoles using copper catalysis is herein reported. The reaction uses readily accessible aryl bromides as coupling partners, including those from heterocycles, and allows easy access to a broad variety of substituted 3-aminoindazoles. The methodology was also examined on other aminoazoles of interest for the pharmaceutical industry.

Copper-catalyzed sequential N-arylation of C-amino-NH-azoles

Copper(ii)-catalyzed boronic acid promoted C-N bond cross-coupling reactions have been successfully developed for sequential N-arylation of C-amino-NH-azoles. These general protocols are compatible with a variety of aryl/hetero-aryl boronic acids and provided rapid access to a diverse array of diarylaminoazole derivatives in a two-step sequence or in one-pot. This journal is

New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors

New 7,8-dihydro-1,6-naphthyridin-5(6H)-one derivatives derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

Synthesis and functionalisation of 1H-pyrazolo[3,4-b]pyridines involving copper and palladium-promoted coupling reactions

A convenient route to novel 3-iodo-1H-pyrazolo[3,4-b]pyridines via iododediazonation of 3-amino-1H-pyrazolo[3,4-b]pyridines, which are obtained by copper-catalysed cyclisation of 2-chloro-3-cyanopyridine with hydrazines. We describe also efficient couplin