7266-32-2

Upstream product

• 67-66-3 chloroform 
• 202344-41-0 1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine 
• 5029-67-4 2-iodopyridine 
• 239137-39-4 3-amino-4-bromopyridine 
• 1069137-36-5 4-(3-nitropyridin-3-yl)pyridine 
• 13091-23-1 4-chloro-3-nitropyridine 

Relevant academic research and scientific papers

TRICYCLIC CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Diazcarbazole derivative, preparation method thereof, and application of diazcarbazole derivative as electroluminescent material

The invention belongs to the technical field of organic photoelectric material application, and particularly relates to a diazcarbazole derivative with different relative positions of N atoms and an application of the diazcarbazole derivative as an electroluminescent material. Carbazole-like group diazcarbazole with an electron-deficient property is introduced, and a triplet state of the materialcan be realized and the molecular orbital energy level can be adjustable through bonding with different groups, so that efficient recombination of carriers in an organic electroluminescent device is achieved fundamentally, an efficient and energy-saving organic light emitting diode (OLED) device is obtained, and the diazcarbazole derivative can be widely applied to the field of organic electroluminescence. The structural general formula of the material is as shown in the formula I, wherein a same diazcarbazole (diazcarbazole with N positions of 1,8, 1,7, 1,6, 2,7, 2,6, 2,5, 3,6, 3,5, and 4,5)is taken as a core, the L group is a bridging group for bonding the diazlocarbazole, the L group is selected from aromatic groups or aromatic heterocyclic groups containing heteroatoms, m and n are the numbers of the diazicarbazole, and the sum of m and n is greater than or equal to 1.

Pyrolysis of 1-substituted pyrazoles and chloroform at 550°C: Formation of α-carboline from 1-benzylpyrazoles

Pyrolysis of 13CH3 labelled 1-methylpyrazole 8 with chloroform at 550°C in a continuous flow reactor yields unlabelled 2-chloropyrimidine 9 and 2-cyanopyrrole 10 labelled at the cyano group. However, pyrolysis of 1-benzylpyrazole 14 with chloroform under similar conditions gives 9,2-phenylpyrimidine 13 and, as the major product, α-carboline 15. Pyrolysis of several substituted 1-(arylmethyl)pyrazoles and the use of 13C and 15N labelled compounds provides direct evidence by which the positions of 7 atoms of 1-benzylpyrazole can be located in the α-carboline. These data support the mechanisms suggested for the formation of 9, 10, and 15.