727-93-5Relevant academic research and scientific papers
Natural product inspired library synthesis - Identification of 2,3-diarylbenzofuran and 2,3-dihydrobenzofuran based inhibitors of Chlamydia trachomatis
Saleeb, Michael,Mojica, Sergio,Eriksson, Anna U.,Andersson, C. David,Gylfe, ?sa,Elofsson, Mikael
supporting information, p. 1077 - 1089 (2017/12/15)
A natural product inspired library was synthesized based on 2,3-diarylbenzofuran and 2,3-diaryl-2,3-dihydrobenzofuran scaffolds. The library of forty-eight compounds was prepared by utilizing Pd-catalyzed one-pot multicomponent reactions and ruthenium-catalyzed intramolecular carbenoid C-H insertions. The compounds were evaluated for antibacterial activity in a panel of test systems including phenotypic, biochemical and image-based screening assays. We identified several potent inhibitors that block intracellular replication of pathogenic Chlamydia trachomatis with IC50 ≤ 3 μM. These new C. trachomatis inhibitors can serve as starting points for the development of specific treatments that reduces the global burden of C. trachomatis infections.
NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
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Example P424; 4065, (2010/11/24)
A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis an
The synthesis of 4-(4-[11C]methoxyphenyl)-5-fluoro-2-hydroxyphenyl)-methylene-aminobutyric acid, as a potential radioligand for the GABA receptor in the brain
De Vos,Slegers
, p. 643 - 652 (2007/10/02)
A procedure for the synthesis of 4-(4-[11C]methoxyphenyl)-(5fluoro-2-hydroxyphenyl)-methylene-aminobutyric acid has been developed. The production entailed a O-methylation of 5-fluoro-2-hydroxy-4'-hydroxybenzophenone with cyclotron produced [s
