72782-48-0

Basic information

• Product Name: 1-methyl-4-[(R)-1-methylallyl]benzene
• Synonyms: 1-methyl-4-[(R)-1-methylallyl]benzene
• CAS NO: 72782-48-0
• Molecular Weight: 146.232
• Mol File: 72782-48-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-methyl-4-[(R)-1-methylallyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-[(R)-1-methylallyl]benzene(72782-48-0)
• EPA Substance Registry System: 1-methyl-4-[(R)-1-methylallyl]benzene(72782-48-0)

Safety Data

• Hazardous Substances Data: 72782-48-0(Hazardous Substances Data)

Upstream product

• 96000-21-4 (E)-p-methylcinnamyl chloride 
• 75-16-1 methylmagnesium bromide 
• 54636-56-5 (E)-1-(3-bromoprop-1-en-1-yl)-4-methylbenzene 
• 104-87-0 4-methyl-benzaldehyde 
• 58824-48-9 1-(4-methylphenyl)-2-propen-1-ol 
• 54636-56-5 3-bromo-1-p-tolyl-1-propene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 201230-82-2 carbon monoxide 
• 74-85-1 ethene 
• 593-60-2 Vinyl bromide 
• 77693-45-9 1-(p-tolyl)ethylmagnesium chloride 

Downstream Products

• 4176-17-4 (R)-(-)-α-curcumene 
• 765916-52-7 (6R)-2-methyl-6-(p-tolyl)hept-2-en-4-ol 
• 1141-54-4 (R)-2-methyl-6-(4-methylphenyl)-2-hepten-4-one 
• 104598-15-4 (R)-3-(4-methylphenyl)butanal 
• 106035-79-4 (R)-3-(4-methylphenyl)-1-butanol 

Relevant articles and documents

Improvements and Applications of the Transition Metal-Free Asymmetric Allylic Alkylation using Grignard Reagents and Magnesium Alanates

Two new N-heterocyclic carbene (NHC) ligands have been synthesized and employed in the transition metal-free asymmetric allylic alkylation (AAA) mediated by Grignard reagents and magnesium alanates. The employment of these ligands showed high yields and improved regio- and enantioselectivity in the formation of tertiary and quaternary stereocenters. Moreover, the low catalyst loading (up to 0.3 mol%) and high scalability (up to 10 mmol) of this improved methodology provide a convenient access to biologically active compounds and synthetically valuable intermediates.

Application of supramolecular bidentate hybrid ligands in asymmetric hydroformylation

In this study we report a novel class of supramolecular bidentate hybrid ligands in which the two inequivalent phosphorus units and pyridine moieties are covalently attached to a chiral scaffold and the supramolecular interactions are used as a second handle to control the coordination sphere around the transition-metal centre. The coordination chemistry of these ligands was investigated under hydroformylation conditions by high-pressure NMR and IR spectroscopy, revealing the formation of a single active species in which the phosphane ligand is in the axial position and the phosphoramidite adopts the equatorial position. These ligands were applied in the asymmetric Rh-catalysed hydroformylation of styrene and para-substituted analogues. In these hydroformylation reactions, modification of the electronic and steric properties of the zinc(II)-templates appear to have a significant influence on the activity and selectivity of the catalysis. In particular, zinc(II)-templates bearing more electron-withdrawing substituents led to an increase in enantioselectivity.

Asymmetrie hydrovinylation of unactivated linear 1,3-dienes

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