72833-05-7

Upstream product

• 99875-11-3 N-benzyl-2-(benzamido)-3-phenylacrylamide 
• 99875-11-3 N-[(1Z)-2-phenyl-1-[[(phenylmethyl)amino]carbonyl]ethenyl]benzamide 
• 100-46-9 benzylamine 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 100-52-7 benzaldehyde 
• 495-69-2 Hippuric Acid 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 
• 1199-01-5 2-phenylazlactone 
• 780-25-6 N-benzylidene benzylamine 

Relevant academic research and scientific papers

Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.

Reaction of benzonitrilium N-phenylimide with (Z)-4-arylmethyleneimidazol-5(4H)-ones

The title reaction, when carried out in chloroform in the presence of triethylamine, yields the spirocycloadducts 5 which upon treatment with a base affords 1,3,4,triaryl-5-pyrazolecarboxamides 12.

Synthesis of 4-Arylidene--1,2-disubstituted-Δ2-imidazolin-5-ones

Addition of 2-substituted-5-oxo-4,5-dihydro-1,3-oxazoles (5-oxazolones) (3) to imines in benzene leads to the formation of 4-arylidene-Δ2-1,3-oxazolin-5-ones (8) which undergo aminolysis and subsequent cyclisation to the corresponding 4-arylidene-1,2-disubstituted-Δ2-imidazolin-5-ones (10) on heating under reflux in gl. acetic acid.