99875-11-3Relevant academic research and scientific papers
Alpha-amino acrylate microbicide and preparation method and application thereof
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Paragraph 0111; 0112; 0113; 0114; 0115; 0253, (2017/10/13)
The invention provides an alpha-amino acrylate microbicide and a preparation method and application thereof. The alpha-amino acrylate microbicide has a specific chemical structure formula shown as a formula I, and the formula I is shown in the description. The alpha-amino acrylate microbicide has the advantages that by utilizing the design principle of pesticide molecules, a medical leading compound with anti-coronavirus activity is performed with structure modification of agricultural plant virus-resisting activity, a series of alpha-amino acrylate derivatives is designed and synthesized, and particularly, the alpha-amino acrylate derivative containing piperidine ring is synthesized; the known compound is used as a positive reference compound to systematically screen the biology activity; a plurality of high-efficiency anti-virus leading molecules are provided for the developing of new pesticides, and the positive meaning is realized for the reduction application of the pesticide and the protection of environment ecology.
Synthesis of 4-benzylidene-oxazol-5(4H)-imines, structural analogs of PK11195, under Bischler-Napieralski conditions
Almaraz-Girón, Marco A.,Vázquez, Alfredo
, p. 785 - 788 (2017/03/31)
A simple and convenient one-pot procedure to prepare 4-benzylidene-2-aryl-1,3-oxazol-5(4H)-imines from phenyl pyruvic acid and a series of arylamides, under classical Bischler-Napieralski (B-N) conditions and microwave heating (MW) has been developed. The
A fast and facile synthesis of n-substituted 2-acylaminoprop-2- enamides using unsaturated azlactones as synthons
Baruah, Hironmayee,Borthakur, Somadrita,Tripathy, Pradeep K.
, p. 205 - 208 (2019/01/21)
A modified route for the fast and facile synthesis of N-substituted 2-acylaminopro- 2-enamides (4) is hereby developed. The conversion of α -N-acylglycine (1) to unstable 2-substituted 2-oxazolin-5-ones (2) was carried out at room temp using ptoluenesulph
Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore
Lee, Cheng-Yu,Chen, Yun-Chung,Lin, Hao-Chun,Jhong, Yuandong,Chang, Chih-Wei,Tsai, Ching-Hua,Kao, Chai-Lin,Chien, Tun-Cheng
, p. 5898 - 5907 (2012/09/07)
A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.
Reaction of benzonitrilium N-phenylimide with (Z)-4-arylmethyleneimidazol-5(4H)-ones
Abdallah,Zayed,Shawali
, p. 187 - 190 (2007/10/03)
The title reaction, when carried out in chloroform in the presence of triethylamine, yields the spirocycloadducts 5 which upon treatment with a base affords 1,3,4,triaryl-5-pyrazolecarboxamides 12.
The Influence of Remote Substituents on Amide Bond Formation. The Reaction of Oxazolinones with Benzylamine
Phelps, David J.,Godreau, Paul V.,Nicholas, Everton S.
, p. 140 - 142 (2007/10/02)
The second-order rate constants for the reaction of nine substituted (Z)-4-benzylidene-2-phenyloxazolin-5-ones with benzylamine in acetonitrile have been obtained.There is an electronic effect in the predicted direction for substitution in either ring.There is a difference in steric effects which appears to be ring specific. ortho-Substituents in the benzylidene ring lead to rate enhancement while ortho-substituents in the phenyl ring retard the rate.The reaction of the oxazolinones with α-methylbenzylamine indicates a large steric effect upon increasing steric demand in the nucleophile.
