72904-47-3Relevant articles and documents
Dimethyl sulfoxide ruthenium(II) complexes of thiosemicarbazones and semicarbazone: Synthesis, characterization and biological studies
Mahalingam, Viswanathan,Chitrapriya, Nataraj,Fronczek, Frank R.,Natarajan, Karuppannan
, p. 2743 - 2750 (2008)
In an attempt to synthesize Ru(II)-dmso-thiosemicarbazone complexes, a series of carbonyl compounds were selected to condense with thiosemicarbazide in ethanol in order to get the respective thiosemicarbazone ligand as the first step. All the selected carbonyl compounds yielded the expected thiosemicarbazone ligand, but the product obtained by the reaction of benzaldehyde with thiosemicarbazide in ethanol was found to show sharp IR peak characteristic of C{double bond, long}O group and thought to be benzaldehyde semicarbazone. When the ligands were treated with cis-[RuCl2(dmso)4)] in ethanol, all the ligands yielded thiosemicarbazone complexes, while the suspected semicarbazone ligand resulted in orange-yellow crystalline product which has been found to be a semicarbazone complex by XRD studies. A mechanism has been proposed for the conversion of C{double bond, long}S to C{double bond, long}O during ligand preparation, which involves the role of adventitious water in ethanol. All the complexes were characterized by analytical and spectroscopic (IR, UV-Vis and 1H NMR) methods. The redox behaviors of the complexes were studied by cyclic voltammetry. The preliminary DNA-binding ability of the complexes was studied by recording electronic absorption spectra of the complexes in presence of herring sperm DNA. Antibacterial activities of the complexes were also been evaluated against five pathogenic bacteria.
Tris-heteroleptic ruthenium(II) polypyridyl complexes: Synthesis, structural characterization, photophysical, electrochemistry and biological properties
Bhat, Satish S.,Dixit, Ruchi,Grampp, Günter,Hey-Hawkins, Evamarie,Khan, Ayesha,Kumbhar, Avinash S.,L?nnecke, Peter,Purandare, Neeraja,Vanka, Kumar
, (2019/11/05)
Three water-soluble tris-heteroleptic ruthenium(II) polypyridyl complexes [Ru(bpy)(phen)(bpg)]2+ (1), [Ru(bpy)(dppz)(bpg)]2+ (2), and [Ru(phen)(dppz)(bpg)]2+ (3) (where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dppz = dipyrido[3,2-a:2′,3′-c] phenazine, bpg = 4b,5,7,7a-tetrahydro-4b,7a-epiminomethanoimino-6H-imidazo[4,5-f] [1,10] phenanthroline-6,13-dione) have been synthesized and characterized. Molecular structures of complexes 1 and 3 are confirmed by single crystal X-ray structure determination. Interaction of complexes 1–3 with DNA is explored by various spectroscopic techniques. The complexes 1–3 show solvent dependent photophysical properties. Complexes 2 and 3 show extensive “molecular light switch” effect for DNA. The complexes 1–3 are low toxic towards HeLa (human cervical cancer) and HL-60 (human promyelocytic leukemia) cell lines. Further, the cellular uptake of complexes 2 and 3 by cells shows that complexes mainly localised on the nucleus of the cells.
Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy
Karges, Johannes,Jakubaszek, Marta,Mari, Cristina,Zarschler, Kristof,Goud, Bruno,Stephan, Holger,Gasser, Gilles
, p. 531 - 542 (2019/11/13)
There is a current surge of interest in the development of novel photosensitizers (PSs) for photodynamic therapy (PDT), as those currently approved are not completely ideal. Among the tested compounds, we have previously investigated the use of RuII
