7291-33-0

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trichloro-N,N-dimethylacetamide is used as a solvent in the pharmaceutical industry for various applications, including the synthesis of active pharmaceutical ingredients and the dissolution of compounds during drug formulation processes. Its ability to dissolve a broad spectrum of substances makes it particularly useful in the development of new medications and the improvement of existing ones.
Used in Agricultural Industry:
In the agricultural sector, 2,2,2-Trichloro-N,N-dimethylacetamide serves as a solvent for the preparation of agrochemicals, such as pesticides and herbicides. Its solvent properties facilitate the formulation of these chemicals, ensuring their effectiveness and ease of application in agricultural settings.
Used in Chemical Industry:
The chemical industry utilizes 2,2,2-Trichloro-N,N-dimethylacetamide for a variety of purposes, including reactions, extractions, and purifications. Its solvent capabilities are instrumental in the synthesis of new compounds and the separation of mixtures, contributing to the advancement of chemical research and product development.
Used as a Solvent for Polymers and Resins:
2,2,2-Trichloro-N,N-dimethylacetamide is also employed as a solvent for various polymers and resins, which are used in the manufacturing of plastics, coatings, adhesives, and other materials. Its ability to dissolve these substances allows for their processing and application in a wide range of industries, from automotive to construction.
Given the potential health risks associated with 2,2,2-Trichloro-N,N-dimethylacetamide, it is essential that it be handled and stored with extreme caution to minimize exposure and ensure the safety of workers and the environment. Proper protective equipment, such as gloves, goggles, and respiratory masks, should be worn when working with this chemical, and it should be stored in well-ventilated areas away from heat and open flames.

InChI:InChI=1/C4H6Cl3NO/c1-8(2)3(9)4(5,6)7/h1-2H3

Upstream product

• 124-40-3 dimethyl amine 
• 76-02-8 trifluoroacetyl chloride 
• 51227-15-7 4-dimethylamino[(dimethylamino)methyl]benzene 
• 75-50-3 trimethylamine 
• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 866-37-5 triethylgermyl dimethylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 677-43-0 N,N-dimethylphosphoroamidic dichloride 
• 76-03-9 trichloroacetic acid 

Downstream Products

• 74305-86-5 C₁₁H₁₂ClNO 
• 684-98-0 1,1,2-Trichloro-2-(dimethylamino)ethen 

Relevant academic research and scientific papers

Dynamic NMR: Field Dependence of the Coalescence Temperature and Temperature Dependence of T2 Relaxation Times in N,N-Dimethyltrichloroacetamide

The field dependence of the 1H and 13C coalescence temperatures in N,N-dimethyltrichloroacetamide has been used to determine the most reliable activation parameters for internal rotation of the amide moiety.The results were found to be in excellent agreement with those obtained earlier by the double-fitting procedure and demonstrate its validity.Direct measurements of the T2 relaxation times of the methyl protons show that T2 depends exponentially on temperature.

Controlling Selectivity in the Synthesis of Z-α,β-Unsaturated Amidines by Tuning the N-Sulfonyl Group in a Rhodium(II) Catalyzed 1,2-H Shift

N2-Sulfonyl-α-diazo amidines can be synthesized by the reaction of electron rich alkynyl amines with electron poor sulfonyl azides through 1,3-dipolar cycloaddition that proceeds with perfect regioselectivity. In the presence of rhodium(II) carboxylate catalysts, denitrogenation occurs to give the corresponding metallocarbene but there are then two competing processes: 1,2–H shift and O-transfer from the sulfonyl group to the metallocarbene center. The outcome can be controlled using an electron poor nitrobenzenesulfonyl group and large carboxylate rhodium ligands to select for 1,2–H shift, forming α,β-unsaturated amidines in high yield and with excellent Z-selectivity.

Primary and Secondary Binding Sites for Lanthanide Shift Reagents with Amides. Differential Behavior of cis vs trans Amide Isomers with LSR

Lanthanide induced shifts (LIS) were measured for four dimethylamides, RCON(CH3)2, and four monomethyl amides, RCONHCH3, R=H, CH3, CF3 and CCl3, using Eu(fod)3 in CCl4 and benzene (C6D6) solution.Structural correlations for HCON(CH3)2 and CH3CON(CH3)2 in both solvents yield a preferred binding site for the Eu(fod)3 on one of the lone-pair orbitals of the oxygen atom, with a probable site of secondary importance on the other lone-pair orbital.The cis vs trans isomers of HCONHCH3 and CH3CONHCH3 exhibit remarkably different chemical shift behavior upon addition of Eu(fod)3.