72936-33-5

Upstream product

• 67-56-1 methanol 
• 108085-99-0 2-(α-nitrobenzyl)-4,4-dimethyl-2-oxazoline 
• 2483-57-0 methyl 2-nitroacetate 
• 3076-54-8 phenyllead(IV) triacetate 
• 622-42-4 1-nitro-1-phenylmethane 
• 79-22-1 methyl chloroformate 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 108-86-1 bromobenzene 
• 111573-07-0 Nitro-phenyl-acetic acid 2-amino-2-methyl-propyl ester; compound with trifluoro-acetic acid 

Downstream Products

• 72936-46-0 N-hydroxyphenylglycine methyl ester 
• 24461-61-8 phenylglycine methyl ester 
• 1380548-85-5 C₁₄H₁₅NO₄ 
• 1380419-35-1 (E)-methyl 2-nitro-2-phenylhepta-4,6-dienoate 

Relevant academic research and scientific papers

4-Amino-1,5-dihydro-2H-pyrrol-2-ones from boron trifluoride catalyzed reactions of 3-amino-2H-azirines with carboxylic acid derivatives

Reaction of 3-amino-2H-azirines 1 with ethyl 2-nitroacetate (6a) in refluxing MeCN affords 4-amino-1,5-dihydro-2H-pyrrol-2-ones 7 and 3,6-diamino-2,5-dihydropyrazines 8, the dimerization product of 1. Thus, 6a reacts with 1 as a CH-acidic compound by C-C

Efficient palladium-catalyzed cross-coupling of highly acidic substrates, nitroacetates

Palladium-catalyzed cross-coupling conditions were developed that efficiently afford 2-aryl-2-nitroacetates from aryl bromides and the very acidic nitroacetates.

Ethynyl-1,2-benziodoxol-3(1H)-one (EBX): An exceptional reagent for the ethynylation of keto, cyano, and nitro esters

Hot alkyne! The in situ generation of ethynyl-1,2-benziodoxol-3(1H)-one (EBX) from a silyl-protected reagent by using TBAF is reported. EBX displayed exceptional acetylene transfer ability onto stabilized enolates (see scheme), even at -78 □°C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano, and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.

New Synthesis of α-Nitroalkyl- and α-Nitroaralkylcarboxylic Esters from α-Nitroalkyl- and α-Nitroaralkyl-2-oxazolines

2-Nitroalkyl- and 2-nitroaralkyl-2-oxazolines are readily converted, in one step, to α-nitroalkyl- and α-nitroaralkylcarboxylic esters on treatment with the appropriate alcohol and trifluoroacetic acid (TFA).The initial products of the ring cleavage are the TFA salts of the ammonioalkyl esters of α-nitroalkyl- and α-nitroaralkylcarboxylic acids.These salts undergo facile transesterification to the α-nitrocarboxylic esters on refluxing with the appropriate alcohol.

A Facile Synthesis of α-Amino Esters via Reduction of α-Nitro Esters Using Ammonium Formate as a Catalytic Hydrogen Transfer Agent

Various nitroesters 3 were selectively and rapidly reduced to their corresponding amino esters 4 in very good yield using anhydrous ammonium formate as a catalytic hydrogen transfer agent.

The Chemistry of Aryllead(IV) Tricarboxylates. The C-Arylation of Nitroalkanes and Nitronate Salts with Aryllead Triacetates

2-Nitropropane reacts with phenyllead triacetate in dimethyl sulfoxide to give 2-nitro-2-phenylpropane in good yield.This arylation of nitroalkanes has been examined with a variety of substrates and a number of aryllead triacetates, and in those cases where there was no steric hindrance the reaction was found to be quite general.Reactions of nitroethane and methyl nitroacetate, compounds with two α-hydrogens, were readily controlled to give either the mono- or di-arylated products.The corresponding nitronate salts were also examined and found to undergo the arylation reaction in similar yield but at a very much faster rate.