7298-73-9

Usage

InChI:InChI=1/C11H15NO2/c1-4-14-11-7-5-10(6-8-11)12(3)9(2)13/h5-8H,4H2,1-3H3

Upstream product

• 1864-93-3 N,N-dimethyl-p-phenetidine 
• 108-24-7 acetic anhydride 
• 698-69-1 4-chloro-N,N-dimethylaniline 
• 62-44-2 4-ethoxyacetanilide 
• 77-78-1 dimethyl sulfate 
• 156-43-4 4-Ethoxyaniline 
• 103-90-2 4-acetaminophenol 
• 74-88-4 methyl iodide 
• 3154-18-5 N-methyl-p-phenetidine 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

REMEDIES FOR NEUROPATHIC PAIN

The present invention relates to a compound represented by Formula (I) below: (wherein A represents, for example, phenyl group substituted by R1 and R2, or an unsubstituted furyl group or an unsubstitued thienyl group; R1 represents, for example, hydrogen atom, fluorine atom, chlorine atom, trifluoromethyl group, nitro group, cyano group or methyl group while R2 represents, for example, hydrogen atom; R3 represents, for example, hydrogen atom or methyl group; R4 represents, for example, hydrogen atom or methyl group; R5 represents ethoxy group or isopropoxy group; X represents group: -CH(OH)- or methylene group; and Z represents, for example, a single bond or methylene group unsubstituted or substituted by hydroxyl group), and its salts, and medicinal compositions containing, as their active ingredient, the above compound or its salts. The compound of this invention, which is orally applicable, is highly effective for treating neuroapthic pain while presenting with fewer side-effects than do the conventional analgesics.

Oxidative Dealkylation of 4-Substituted N,N-Dialkylanilines with Molecular Oxygen in the Presence of Acetic Anhydride Promoted by Cobalt(II) or Copper(I) Chloride

The reaction of 4-substituted N,N-dimethylanilines 1a-d with acetic anhydride 5 proceeded efficiently in the presence of a catalytic amount of cobalt(II) or copper(I) chloride under oxygen to give the corresponding N-methylacetanilides 2a-d along with N-methylformanilides 3a-d.The reaction of N-alkyl-N-methyl-p-toluidines 1f-h with cobalt chloride revealed that the order of reactivity of the N-substituents follows the sequence allyl > benzyl >/= methyl > ethyl, while in the case of copper chloride the order was benzyl > allyl > methyl > ethyl.Aldehydes 18a-e and phenylglyoxylic acid derivatives 18f and 18g were obtained in fair to good yield from the reaction of n-substituted N-ethyl-p-toluidines 17a-g.

Cobalt(II) Chloride Catalyzed Oxidation of 4-Substituted N,N-Dialkylanilines with Molecular Oxygen in the Presence of Acetic Anhydride

The oxidation of 4-substituted N,N-dialkylanilines with molecular oxygen using a catalytic amount of cobalt(II) chloride efficiently proceeds in the presence of acetic anhydride to give N-alkylacetanilides in good yields along with N-alkylformanilides.