7298-87-5

Basic information

• Product Name: 1,3-Cyclohexanedione, 2-bromo-2-chloro-5,5-dimethyl-
• CAS NO: 7298-87-5
• Molecular Formula: C8H10BrClO2
• Molecular Weight: 253.523
• Mol File: 7298-87-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3-Cyclohexanedione, 2-bromo-2-chloro-5,5-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Cyclohexanedione, 2-bromo-2-chloro-5,5-dimethyl-(7298-87-5)
• EPA Substance Registry System: 1,3-Cyclohexanedione, 2-bromo-2-chloro-5,5-dimethyl-(7298-87-5)

Safety Data

• Hazardous Substances Data: 7298-87-5(Hazardous Substances Data)

Usage

Type of Compound

Cyclic diketone

Structural Features

Contains a six-membered carbon ring (cyclohexane)
Two carbonyl groups (C=O) at the 1 and 3 positions
A bromine atom at the 2 position
A chlorine atom at the 2 position
Two methyl groups (CH3) at the 5 and 5 positions

Applications

Organic synthesis
Reagent in chemical reactions
Building block in the synthesis of various drugs and pharmaceuticals
Precursor in the preparation of complex organic molecules
Development of new materials and chemical processes

Safety Precautions

Handle with caution due to potential health hazards if not properly managed.

Upstream product

• 67-66-3 chloroform 
• 1195-91-1 2-bromodimedone 
• 37722-34-2 2-bromo-5,5-dimethyl-3-hydroxycyclohex-2-en-1-one 
• 70990-68-0 2-chloro-3-hydroxy-5,5-dimethylcyclohex-2-enone 
• 7298-89-7 2-chloro-5,5-dimethyl-1,3-cyclohexanedione 
• 7732-18-5 water 
• 7726-95-6 bromine 

Downstream Products

• 7298-89-7 2-chloro-5,5-dimethyl-1,3-cyclohexanedione 

Relevant articles and documents

Production mechanism of active species on the oxidative bromination following perhydrolase activity

Hypobromous acid and molecular bromine have been described as the active species involved in the oxidative bromination using perhydrolase, which catalyzes the reaction from acetic acid and hydrogen peroxide to peracetic acid (AcOOH). However, the brominating activity of them in a chemical model system was lower than that of the active species produced by the spontaneous reaction between AcOOH and Br-. Consequently, acetyl hypobromite (AcOBr) was suggested as new active species on the bromination by detection of the decarboxylation in the reaction between AcOOH and Br- and the strong brominating power with some tolerance against H2O2. Its production mechanism was explained as the ionic reaction involving the protonated intermediate of AcOOH by kinetic analysis.

The (Schiff base)vanadium(v) complex catalyzed oxidation of bromide - A new method for the in situ generation of bromine and its application in the synthesis of functionalized cyclic ethers

(Schiff base)vanadium(v) complexes 5 with tridentate imine auxiliaries served as catalysts for the oxidation of Br with tert-butyl hydroperoxide (TBHP) in nonaqueous solvents. This reaction has been applied for the conversion of substituted 4-penten-1-ols into 5-exo-bromo-cyclized products, including a diastereomerically pure heterocyclic precursor used in a synthesis of the all-trans-configured 2,3,4,5-substituted tetrahydrofuran 2-epi-magnosalicin. Treatment of co-substituted bis(homoallylic) alcohols with the reagent combination of pyHBr, TBHP, and a vanadium(v) catalyst 5 afforded 6-endo-cyclized products, i.e. brominated tetrahydropyrans, as major compounds. The results from 51V NMR, ESI-MS, and supporting reactivity- selectivity studies indicated that the mechanism of the new bromination reaction consists of vanadium-dependent and vanadium-independent steps. A (Schiff base)vanadium(v) compound 5 is required for activation of TBHP via in situ formation of the corresponding tert-butylperoxy complex. This reagent oxidizes Br-, which under the reaction conditions provides Br2 as the active brominating reagent. The molecular bromine generated thus is released into the solution at a steady rate and serves as a reagent for the synthesis of β-brominated cyclic ethers from bis(homoallylic) alcohols in a second, vanadium-independent step. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.