73013-68-0

Basic information

• Product Name: 6-ACETYLQUINOLINE
• Synonyms: 6-ACETYLQUINOLINE;1-Quinolin-6-ylethanone;NSC 87613;1-(Quinolin-6-yl)
• CAS NO: 73013-68-0
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 73013-68-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 77 °C
• Boiling Point: 315.2 °C at 760 mmHg
• Flash Point: 152.4 °C
• Appearance: /
• Density: 1.154 g/cm³
• Vapor Pressure: 0.000444mmHg at 25°C
• Refractive Index: 1.621
• PKA: 3.99±0.10(Predicted)
• CAS DataBase Reference: 6-ACETYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ACETYLQUINOLINE(73013-68-0)
• EPA Substance Registry System: 6-ACETYLQUINOLINE(73013-68-0)

Safety Data

• Hazardous Substances Data: 73013-68-0(Hazardous Substances Data)

Usage

General Description

6-Acetylquinoline is an organic chemical compound with the formula C11H9NO. It is a yellow crystalline solid that is commonly used as a building block in the synthesis of pharmaceuticals, dyes, and other organic compounds. 6-Acetylquinoline is known for its powerful antioxidant and anti-inflammatory properties, making it a potential candidate for the development of new drugs for various medical applications. It is also used in the production of fluorescence dyes and as a reagent in chemical analysis. Despite its potential uses, 6-Acetylquinoline is known to be hazardous to human health and should be handled with care to avoid exposure.

InChI:InChI=1/C11H9NO/c1-8(13)9-4-5-11-10(7-9)3-2-6-12-11/h2-7H,1H3

Upstream product

• 10349-57-2 Quinoline-6-carboxylic acid 
• 99-92-3 p-aminobenzophenone 
• 504-63-2 trimethyleneglycol 
• 56-81-5 glycerol 
• 408309-80-8 2-chloro-1-(1,2,3,4-tetrahydroquinolin-6-yl)ethanone 
• 4113-04-6 quinoline-6-carbaldehyde 
• 179873-51-9 N-methoxy-N-methylquinoline-6-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 14002-34-7 tripropanolamine 
• 100-19-6 (4-nitrophenyl)ethanone 
• 156-87-6 propan-1-ol-3-amine 
• 3179-63-3 3-Dimethylamino-1-propanol 
• 113961-88-9 6-Acetyl-1,2,3,4-tetrahydroquinoline 
• 73987-38-9 quinoline-6-carboxylic acid ethyl ester 

Downstream Products

• 5622-38-8 ethyl 6-quinolineacetate 
• 1426130-29-1 3-phenyl-1-(quinolin-6-yl)prop-2-yn-1-one 
• 97596-07-1 Brommethyl--keton 

Relevant articles and documents

Mild Cu-Catalyzed Oxidation of Benzylic Boronic Esters to Ketones

The oxidation of benzylic boronic esters directly to the ketone is reported. This mild Cu-catalyzed method uses an ambient atmosphere of air as the terminal oxidant and is notably chemoselective. Oxidation of the C-B bond occurs selectively, even in the presence of unprotected alcohols. Initial investigation suggests the reaction proceeds through an alkylboron to Cu transmetalation, peroxide formation, and rearrangement to give the carbonyl.

Preparation method of quinoline derivative

The invention provides a preparation method of a quinoline derivative. The method includes the steps of: in the presence of an oxidizing agent, adding a catalyst, then adding aniline or aromatic amine with different substituents, at the same time adding alcohol for reaction so as to prepare the quinoline derivative by one step. Specifically, the catalyst comprises a metal catalyst, an assistant catalyst I and an assistant catalyst II; the metal catalyst is a transition metal catalyst; the assistant catalyst I is an alkaline nitrogen-containing ligand; and the assistant catalyst II is an acidic compound. The quinoline derivative prepared by the method provided by the invention has stable performance and high purity. And the preparation method of the quinoline derivative can prepare quinoline, 2-methylquinoline, 8-hydroxyquinoline quinoline and other derivatives by one-step reaction, and the preparation method is simple and practicable. The preparation process does not produce new "three wastes", is environment-friendly, and provides a green and environment-friendly synthesis method. The preparation method has the characteristics of few raw material variety, little reaction equipment, few preparation step and low cost, and is more suitable for industrial production.

Quinoline compounds and preparation method thereof, and intermediate, pharmaceutical composition and application of quinoline compounds

The invention discloses quinoline compounds and a preparation method thereof, and an intermediate, a pharmaceutical composition and application of quinoline compounds. The invention provides quinoline compounds disclosed as Formula 1, and pharmaceutically acceptable salts, solvates, metabolites, metabolism precursors or pharmaceutical precursors thereof. The quinoline compounds have favorable inhibitory effects on tyrosine kinase C-Met, and can be used for preparing drugs for prevention, treatment or auxiliary treatment on multiple diseases related to C-Met expression or activity, and especially neoplastic diseases.