73083-33-7

Basic information

• Product Name: [S,(+)]-3-O-Benzyl-1-O,2-O-dimyristoyl-L-glycerol
• Synonyms: [S,(+)]-3-O-Benzyl-1-O,2-O-dimyristoyl-L-glycerol
• CAS NO: 73083-33-7
• Molecular Formula: C₃₈H₆₆O₅
• Molecular Weight: 602.93
• Mol File: 73083-33-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [S,(+)]-3-O-Benzyl-1-O,2-O-dimyristoyl-L-glycerol(CAS DataBase Reference)
• NIST Chemistry Reference: [S,(+)]-3-O-Benzyl-1-O,2-O-dimyristoyl-L-glycerol(73083-33-7)
• EPA Substance Registry System: [S,(+)]-3-O-Benzyl-1-O,2-O-dimyristoyl-L-glycerol(73083-33-7)

Safety Data

• Hazardous Substances Data: 73083-33-7(Hazardous Substances Data)

Upstream product

• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 112-64-1 tetradecanoyl chloride 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 
• 100-39-0 benzyl bromide 
• 544-63-8 n-tetradecanoic acid 
• 14347-83-2 (R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane 
• 16495-03-7 (S)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-44-7 benzyl chloride 
• 15028-56-5 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 1069-82-5 1,2-di-O-myristoyl-sn-glycerol 
• 20255-94-1 1,2-dimyristoyl-rac-glycerol 
• 260392-69-6 (2R)-3-(((benzyloxy)(diisopropylamino)phosphanyl)oxy)propane-1,2-diyl ditetradecanoate 
• 60562-16-5 1,2-dimyristoyl-sn-glycerol 

Relevant articles and documents

The Chiral Target of Daptomycin Is the 2R,2′S Stereoisomer of Phosphatidylglycerol

Daptomycin (dap) is an important antibiotic that interacts with the bacterial membrane lipid phosphatidylglycerol (PG) in a calcium-dependent manner. The enantiomer of dap (ent-dap) was synthesized and was found to be 85-fold less active than dap against

COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

Synthesis of boron cluster lipids: Closo-dodecaborate as an alternative hydrophilic function of boronated liposomes for neutron capture therapy

(Chemical Equation Presented) We succeeded in the synthesis of the double-tailed boron cluster lipids 4a-c and 5a-c, which have a B 12H11S moiety as a hydrophilic function, by S-alkylation of B12H11SH (BSH) with bromoacetyl and chloroacetocarbamate derivatives of diacylglycerols for a liposomal boron delivery system on neutron capture therapy. Calcein encapsulation experiments revealed that the liposomes, prepared from the boron cluster lipid 4b, DMPC, PEG-DSPE, and cholesterol, are stable at 37°C in FBS solution for 24 h.