73096-27-2

Basic information

• Product Name: 1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: AKOS BBS-00001533;1-[(4-CHLOROPHENYL)SULFONYL]PYRROLIDINE-2-CARBOXYLIC ACID;1-[(4-CHLOROPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID;1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID;CBI-BB ZERO/006267;TIMTEC-BB SBB012273;2-[(4-Chlorophenyl)sulfonyl]-2-pyrrolidinecarboxylic acid;1-(4-chlorophenyl)sulfonylproline
• CAS NO: 73096-27-2
• Molecular Formula: C₁₁H₁₂ClNO₄S
• Molecular Weight: 289.74
• Mol File: 73096-27-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 102-105°C
• Boiling Point: 483.7°C at 760 mmHg
• Flash Point: 246.3°C
• Appearance: /
• Density: 1.515±0.06 g/cm3(Predicted)
• Vapor Pressure: 3.62E-10mmHg at 25°C
• PKA: 3.34±0.20(Predicted)
• CAS DataBase Reference: 1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID(73096-27-2)
• EPA Substance Registry System: 1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID(73096-27-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 73096-27-2(Hazardous Substances Data)

Usage

General Description

1-(4-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid is a chemical compound with the molecular formula C13H14ClNO4S. It is a pyrrolidine derivative containing a carboxylic acid and a chloro-benzenesulfonyl group. 1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID has been identified as a potential inhibitor of the enzyme aldose reductase, which has implications in diabetic complications and other diseases. It is also utilized in the synthesis of various pharmacologically active molecules. The presence of the chloro-benzenesulfonyl group makes this compound useful in organic synthesis as a protecting group for amines and other functional groups. Overall, 1-(4-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid has diverse applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C11H12ClNO4S/c12-8-3-5-9(6-4-8)18(16,17)13-7-1-2-10(13)11(14)15/h3-6,10H,1-2,7H2,(H,14,15)/p-1/t10-/m1/s1

Upstream product

• 255053-75-9 (S)-9-{N-(p-chlorophenylsulfonyl)prolinyl}-β-carboline 
• 88867-97-4 (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carbonyl chloride 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 147-85-3 L-proline 
• 147-85-3 L-proline 

Downstream Products

• 1375314-05-8 1,3-bis[N'-(4-chlorophenylsulfonyl)-N-methyl-(S)-prolinamidomethyl]-1,1,3,3-tetramethyl-1,3-disiloxane 
• 88867-91-8 (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((S)-1-phenyl-ethyl)-amide 
• 88867-90-7 (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 255053-75-9 (S)-9-{N-(p-chlorophenylsulfonyl)prolinyl}-β-carboline 
• 88867-97-4 (S)-1-(4-Chloro-benzenesulfonyl)-pyrrolidine-2-carbonyl chloride 

Relevant articles and documents

HETEROCYCLIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME

Compound represented by formula (I): wherein each symbol is as defined herein, exhibit TRPA1 antagonist activity, and are useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

Diastereomeric ester compound useful as an intermediate in the making of an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound

The present invention provides a new diastereomer ester compound which is useful as an intermediate in the making of an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound.

Synthesis and Liquid Chromatographic Evalution of Some Chiral Derivatizing Agents for Resolution of Amine Enantiomers

A series of 1-prolyl chlorides were synthesized and evaluated as chiral derivatizing agents for the liquid chromatographic analysis of enantiomeric amines.The diastereomeric 1-prolinamides showed st